Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

510 questions · 533 findings · 60 reviews

No studies found 153 · 28.7%GRADE not reported 18 · 3.4%Very low 134 · 25.1%Low 123 · 23.1%Moderate 80 · 15%High 25 · 4.7%

Distal splenorenal shunt vs endoscopic intervention

Mortality due to rebleeding · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether distal splenorenal shunt changes mortality due to rebleeding compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Distal splenorenal shunt vs endoscopic intervention

Acute hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether distal splenorenal shunt changes acute hepatic encephalopathy compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Distal splenorenal shunt vs endoscopic intervention

Chronic hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether distal splenorenal shunt changes chronic hepatic encephalopathy compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Total shunt vs endoscopic intervention

All‐cause mortality · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether total shunt changes all‐cause mortality compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Vaginal misoprostol vs placebo

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes pain (opiate use) compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Duration of hospitalization (in weeks) · individuals with infant botulism
1 finding from 1 review