Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,954 questions · 2,335 findings · 149 reviews · All outcomes

No studies found 436 · 18.7%GRADE not reported 1,370 · 58.7%Very low 254 · 10.9%Low 173 · 7.4%Moderate 80 · 3.4%High 22 · 0.9%

Cesarean section delivery vs Vaginal delivery

Early childhood caries (ECC) · Children with average age >3 years

No significant association between cesarean vs vaginal delivery and ECC among children with average age >3 years (OR 1.24, 95% CI 0.89-1.71).

1 finding from 1 review

Non-surgical orthodontic treatment (any: facemask, chin cup, tandem traction bow, mandibular headgear, ORTA, reverse Twin Block, Reverse Forsus) vs no treatment

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Non-surgical orthodontic treatment (any: facemask, chin cup, tandem… led to higher wits appraisal compared with no treatment; GRADE not reported.

1 finding from 1 review

Facemask with rapid maxillary expansion (RME) vs Pushing Splints

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask with rapid maxillary expansion (RME) showed no clear difference in wits appraisal compared with pushing Splints; GRADE not reported.

1 finding from 1 review

Consumption of xylitol chewing gum by women (mothers) vs Consumption of CHX/xylitol gum by women, or CHX varnish applied to women's dentition

Mother microbiological presence (mutans streptococci colonisation level, CFU/mL) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age

Consumption of xylitol chewing gum by women (mothers) led to higher mother microbiological presence (mutans streptococci colonisation… compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to…; GRADE not reported.

1 finding from 1 review

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries · Children aged 2 to 8 years

The review reported an OR of 1.32 when prenatal vitamin D was measured at 6 to 38 gestational weeks.

2 findings from 1 review

Facemask vs no intervention

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask probably leads to higher ANB compared with untreated control (no treatment) (moderate certainty).

3 findings from 1 review

Facemask with rapid maxillary expansion (RME) vs Pushing Splints

Adverse effects · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
1 finding from 1 review

Consumption of xylitol chewing gum by women (mothers) vs Consumption of CHX/xylitol gum by women, or CHX varnish applied to women's dentition

defs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age

It is very uncertain whether consumption of xylitol chewing gum by women (mothers) changes defs index score (categories) compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to… (very low certainty).

2 findings from 1 review

Facemask (RME) or modified facemask vs Surgically-anchored appliance (miniscrews or miniplates)

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask (RME) or modified facemask showed no clear difference in wits appraisal compared with surgically-anchored appliance (miniscrews or miniplates); GRADE not reported.

1 finding from 1 review

Facemask with rapid maxillary expansion (RME) vs Pushing Splints

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask with rapid maxillary expansion (RME) showed no clear difference in overjet compared with pushing Splints; GRADE not reported.

1 finding from 1 review

Facemask vs no intervention

Self-esteem (Oral Aesthetic Subjective Impact Score, OASIS) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask led to lower self-esteem (Oral Aesthetic Subjective Impact Score, OASIS) compared with untreated control (no treatment); GRADE not reported.

3 findings from 1 review

Bone-anchored intermaxillary traction (BAIMT) vs Removable mandibular retractor (RMR)

Adverse effects / patient-reported (pain, self-confidence) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
1 finding from 1 review

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries in children · Children aged 6 to 8 years whose mothers' prenatal vitamin D status was assessed

In the single study of children aged 6-8 years, the association was not statistically significant (OR 1.07, 95% CI 0.84-1.30); ungraded.

1 finding from 1 review

Facemask after Alt-RAMEC vs Facemask started simultaneously with Alt-RAMEC

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask after Alt-RAMEC showed no clear difference in ANB compared with facemask started simultaneously with Alt-RAMEC; GRADE not reported.

1 finding from 1 review

Oral health education/promotion (oral hygiene advice plus diet and feeding practice advice) combined with clinical treatment for mother's dentition (basic restorative and preventive; 1 trial included CHX varnish application) vs usual care

Child oral health behaviours · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
1 finding from 1 review

Facemask after Alt-RAMEC vs Facemask started simultaneously with Alt-RAMEC

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask after Alt-RAMEC showed no clear difference in wits appraisal compared with facemask started simultaneously with Alt-RAMEC; GRADE not reported.

1 finding from 1 review

Surgically-anchored orthodontic treatment (miniplates) vs no intervention

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Surgically-anchored orthodontic treatment (miniplates) may leads to higher ANB compared with untreated control (no treatment) (low certainty).

1 finding from 1 review

Breastfeeding promotion and support (e.g. individually tailored home-based peer counselling on the importance of breastfeeding, with advice and support for healthy breastfeeding) vs usual care

Dental caries · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age

The review found no eligible studies for this question.

2 findings from 1 review

Surgical miniplates with facemask vs Surgical miniplates with Class III elastics

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Surgical miniplates with facemask showed no clear difference in overjet compared with surgical miniplates with Class III elastics; GRADE not reported.

1 finding from 1 review