Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Nicotine replacement therapy vs placebo

Change in weight (kg) · People who have quit smoking

Nicotine replacement therapy for smoking cessation showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (moderate certainty).

3 findings from 1 review

Varenicline vs placebo

Change in weight (kg) · People who have quit smoking

Varenicline for smoking cessation showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (high certainty).

3 findings from 1 review

Fluoexetine vs placebo

Change in weight (kg) · People who have quit smoking

Fluoexetine showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (low certainty).

2 findings from 1 review

Behavioural weight management interventions vs brief advice or no intervention

Smoking cessation · People wanting to quit smoking

Behavioural weight management interventions showed no clear difference in smoking cessation at 6 months ‐ Weight management education versus… compared with brief advice or no intervention (low certainty).

2 findings from 1 review

5‐HT3 antagonists vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

5‐HT3 antagonists may leads to lower nausea ‐ intraoperative compared with placebo (low certainty).

2 findings from 1 review

Corticosteroids vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

Corticosteroids probably leads to lower nausea ‐ postoperative compared with placebo (moderate certainty).

2 findings from 1 review

Anticholinergic medication vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

Anticholinergics may leads to lower nausea ‐ intraoperative compared with placebo (low certainty).

2 findings from 1 review

Sedation vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

Sedatives probably leads to lower nausea ‐ intraoperative compared with placebo (moderate certainty).

2 findings from 1 review

Dopamine antagonists vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

It is very uncertain whether dopamine antagonists changes nausea ‐ intraoperative compared with placebo (very low certainty).

2 findings from 1 review