Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,938 questions · 1,994 findings · 246 reviews · Headline outcomes only

No studies found 490 · 24.6%GRADE not reported 71 · 3.6%Very low 669 · 33.6%Low 446 · 22.4%Moderate 264 · 13.2%High 54 · 2.7%

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ pre‐ and postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

SLNB vs observation

Surgical Morbidity (Within 30 d) Related to the Regional Nodal Basin in Patients Assigned to the 2 Treatment Arms of MSLT‐I Any complication in the dissected basin, regional or systemic related to the surgical treatment in the regional nodal basin · patients with localised primary cutaneous melanoma

SLNB may leads to higher surgical Morbidity (Within 30 d) Related to the Regional Nodal Basin… compared with observation (low certainty).

1 finding from 1 review

SLNB vs observation

Surgical Morbidity (Within 30 d) Related to Wide Excision of the Primary Site in Patients Assigned to the 2 Treatment Arms of MSLT‐I Any Surgical Complication related to the wide excision site · patients with localised primary cutaneous melanoma

SLNB showed no clear difference in surgical Morbidity (Within 30 d) Related to Wide Excision of the… compared with observation (low certainty).

1 finding from 1 review

Combined oral and intravenous vs oral or intravenous alone

Wound infection · colorectal surgery

Combined oral and intravenous leads to lower surgical wound infection: oral + iv versus iv alone compared with oral or intravenous alone (high certainty).

2 findings from 1 review

Intervention not reported

Reduction in number and/or frequency of surgical interventions and/or time until first relapse requiring surgery · 23 patients aged two years or older with recurrent respiratory papillomatosis

The review found no eligible studies for this question.

1 finding from 1 review

Minimal invasive discectomy vs micro/discectomy

Side effects ‐ surgical site and other infections > 6 months' · participants with lumbar disc herniation

Minimal invasive discectomy probably leads to lower side effects ‐ surgical site and other infections > 6 months' compared with micro/discectomy (moderate certainty).

1 finding from 1 review

Intervention not reported

Perioperative bleeding requiring non‐surgical intervention · patients with paediatric tonsillectomy

The intervention showed no clear difference in perioperative bleeding requiring non‐surgical intervention (moderate certainty).

1 finding from 1 review