Any severe adverse event during maintenance treatment · people with Crohn's disease who responded to CZP remission‐induction treatment
Certolizumab pegol showed no clear difference in serious adverse events during remission maintenance treatment(1 RCT,… compared with placebo (low certainty).
1 finding from 1 review
RR 0.84 [0.4, 1.78]
Studies not reported
Low
Recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
Intensification of prophylactic therapy guided by colonoscopy showed no clear difference in clinical recurrence ( compared with intensification guided by clinical recurrence (low certainty).
1 finding from 1 review
Mortality ( · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
1 finding from 1 review
Quality of life · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects ( · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
It is very uncertain whether initiation of prophylactic therapy guided by colonoscopy changes adverse effects ( compared with initiation of prophylactic therapy immediately after surgery (very low certainty).
1 finding from 1 review
Endoscopic recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
Intensification of prophylactic therapy guided by colonoscopy may leads to lower endoscopic recurrence ( compared with intensification guided by clinical recurrence (low certainty).
1 finding from 1 review
Surgical recurrence ( · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
1 finding from 1 review
no estimate extracted
504 participants
Very low
Mortality ( · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
1 finding from 1 review
Quality of life · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects ( · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
It is very uncertain whether intensification of prophylactic therapy guided by colonoscopy changes adverse effects ( compared with intensification guided by clinical recurrence (very low certainty).
1 finding from 1 review
Clinical recurrence (until week 102) · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
It is very uncertain whether initiation of prophylactic therapy guided by colonoscopy changes clinical recurrence (until week 102) compared with initiation of prophylactic therapy immediately after surgery (very low certainty).
1 finding from 1 review
Endoscopic recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
It is very uncertain whether initiation of prophylactic therapy guided by colonoscopy changes endoscopic recurrence (at week 102) compared with initiation of prophylactic therapy immediately after surgery (very low certainty).
1 finding from 1 review
Surgical recurrence ( · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
It is very uncertain whether initiation of prophylactic therapy guided by colonoscopy changes surgical recurrence ( compared with initiation of prophylactic therapy immediately after surgery (very low certainty).
1 finding from 1 review
RR 0.79 [0.38, 1.62]
133 participants
Very low
Remission · Patients with active Crohn's disease
It is very uncertain whether intervention diet changes induction of remission at 4 weeks ‐ High‐fiber, low refined… compared with control diet (very low certainty).
4 findings from 1 review
Show 1 more finding
Clinical relapse · Participants with Crohn's disease in remission
Intervention diet showed no clear difference in clinical relapse at 6 to 24 months ‐ Symptoms‐guided diet compared with control diet (low certainty).
4 findings from 1 review
RR 0.53 [0.28, 1.01]
2 studies · 98 participants
Low
RR 1.03 [0.85, 1.26]
1 study · 214 participants
Low
RR 0.11 [0.01, 1.76]
1 study · 54 participants
Very low
Show 1 more finding
Health‐related quality of life · Participants with Crohn's disease in remission
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · Participants with Crohn's disease in remission
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Induction of remission (timeframe not reported) ‐ Symptoms‐guided diet · Patients with active Crohn's disease
It is very uncertain whether intervention diet changes induction of remission (timeframe not reported) ‐ Symptoms‐guided diet compared with control diet (very low certainty).
1 finding from 1 review
Health‐related quality of life (timeframe not reported) ‐ IBDQ ‐ Symptoms‐guided diet · Patients with active Crohn's disease
1 finding from 1 review
QoL · Patients with active Crohn's disease
1 finding from 1 review