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Evidence found and GRADE certainty

2,123 questions · 2,188 findings · 243 reviews

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No studies found 493 · 22.5%GRADE not reported 160 · 7.3%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.6%High 97 · 4.4%

Antibiotics vs other antibiotics

Adverse events considered non‐serious (penicillin versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious (penicillin versus doxycycline) compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Non‐serious adverse events Maximum · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious (penicillin versus… compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

All‐cause mortality (penicillin versus a cephalosporin (cefotaxime or ceftriaxone)) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes all‐cause mortality (penicillin versus a cephalosporin (cefotaxime… compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

All‐cause mortality (penicillin versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes all‐cause mortality (penicillin versus doxycycline) compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

All‐cause mortality (a cephalosporin (cefotaxime) versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes all‐cause mortality (a cephalosporin (cefotaxime) versus doxycycline) compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Serious adverse events (nosocomial infection) (penicillin versus cefotaxime) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes serious adverse events (nosocomial infection) (penicillin versus… compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Serious adverse events (nosocomial infection) (penicillin versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes serious adverse events (nosocomial infection) (penicillin versus… compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Serious adverse events (nosocomial infection) (doxycycline versus cefotaxime) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes serious adverse events (nosocomial infection) (doxycycline versus… compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs no antibiotics

Clinical pregnancy rate · embryo transfer (ET) in assisted reproductive technology (ART)

Summary of findings table ‐ Antibiotics showed no clear difference in clinical pregnancy rate (CPR) compared with control (no antibiotics) (low certainty).

1 finding from 1 review

Antibiotics vs no antibiotics

Genital Tract Colonisation · embryo transfer (ET) in assisted reproductive technology (ART)

It is very uncertain whether summary of findings table ‐ Antibiotics changes genital tract colonization compared with control (no antibiotics) (very low certainty).

1 finding from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Complete resolution of endophthalmitis at 3 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

It is very uncertain whether combined steroid and antibiotic therapy changes complete resolution of endophthalmitis at 3 months' compared with antibiotics alone (very low certainty).

1 finding from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Visual acuity · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy may leads to higher visual acuity 6/6 to 6/18 at 3 months' compared with antibiotics alone (low certainty).

2 findings from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Adverse events at 3 to 12 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy showed no clear difference in adverse events at 3 to 12 months' compared with antibiotics alone (low certainty).

1 finding from 1 review