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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Technique to increase peri-implant keratinised/attached mucosa vs No increase of keratinised/attached mucosa

Outcome not reported · Patients receiving dental implants

The review found no eligible studies for this question.

1 finding from 1 review

Intraoral vertical ramus osteotomy (IVRO) vs Sagittal split ramus osteotomy (SSRO)

Stability of correction: sagittal changes of pogonion (1 week to 1 year) · Adults (16 years of age or older) with an Angle Class III malocclusion (prominent lower front teeth); people with syndromes, clefts or…

Intraoral vertical ramus osteotomy (IVRO) showed no clear difference in stability of correction: sagittal changes of pogonion (1 week to 1… compared with sagittal split ramus osteotomy (SSRO); GRADE not reported.

1 finding from 1 review

HAART regimen + topical treatment vs HAART alone

Incidence and recurrence after healing of ulcers · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
    No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Average number of new lesions per week · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) led to lower number of new lesions per day compared with placebo; GRADE not reported.

1 finding from 1 review

Tetracycline suspension (250 mg, held in mouth 2 minutes then swallowed, four times daily for 5 days) vs placebo

Adjusted maximum ulcer size and adjusted maximum pain · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

LongoVital (herbal component alone) vs placebo

Number of ulcer-free days and number of new ulcers · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
    4 months
    Kolseth 2005 (high risk of bias): 40 patients randomised to the herbal component of LongoVital alone or placebo; data presented as medians with 95% CIs, unsuitable for further analysis; no statistically significant…
    1 study · 40 participants
    GRADE not reported

Tooth/implant FDP with rigid connectors vs Tooth/implant FDP with non-rigid connectors

Non-scheduled maintenance visits · Patients with tooth/implant-supported FDPs; split-mouth
1 finding from 1 review

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs placebo

Frequency of outbreaks per month · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) led to lower frequency of outbreaks per month compared with placebo; GRADE not reported.

1 finding from 1 review

Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD

Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

One suturing technique/material vs A different suturing technique/material

Outcome not reported · Patients receiving dental implants

The review found no eligible studies for this question.

1 finding from 1 review

Intraoral vertical ramus osteotomy (IVRO) vs Sagittal split ramus osteotomy (SSRO)

Stability of correction: vertical changes of B-point (1 week to 1 year) · Adults (16 years of age or older) with an Angle Class III malocclusion (prominent lower front teeth); people with syndromes, clefts or…

Intraoral vertical ramus osteotomy (IVRO) showed no clear difference in stability of correction: vertical changes of B-point (1 week to 1… compared with sagittal split ramus osteotomy (SSRO); GRADE not reported.

1 finding from 1 review

Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline

Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Tetracycline suspension (250 mg, held in mouth 2 minutes then swallowed, four times daily for 5 days) vs placebo

Average number of new lesions per week · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Tetracycline suspension (250 mg, held in mouth 2 minutes then… showed no clear difference in average number of new lesions per week compared with placebo; GRADE not reported.

1 finding from 1 review