What do systematic reviews say?

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Er:YAG laser surface debridement before bone augmentation vs Plastic curettes plus saline solution before bone augmentation

Change in soft tissue recession (REC) · People with at least one dental implant affected by perimplantitis

Er:YAG laser surface debridement before bone augmentation showed no clear difference in change in soft tissue recession (REC) compared with plastic curettes plus saline solution before bone augmentation; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes
6 months
Six months after treatment there were no statistically significant differences for soft tissue recessions.
1 study · 30 participants
GRADE not reported

Sodium hypochlorite 1% with chlorhexidine 2% final rinse vs Sodium hypochlorite 1% with normal saline final rinse

Adverse effects · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Chlorhexidine, 0.2% to 2% (solution or gel)

Proportion of participants with new or worsening signs/symptoms of inflammation requiring a revisit, up to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Aloe vera gel vs placebo

Primary outcome: partial clinical response · People with erosive oral lichen planus

Aloe vera gel led to higher partial response (>=50% clinical improvement) compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 19.25 [2.83, 130.85]
1 study · 45 participants
GRADE not reported

Aloe vera gel vs placebo

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Choonhakarn 2008: no serious side-effects; 2 participants receiving aloe vera gel reported stinging and mild itching at lesions within the first week, symptoms spontaneously disappeared with…
1 study · 45 participants
GRADE not reported

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

Pain free by end of study (day 6) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Individualised homeopathic medicine (two doses over 24 hours) led to higher pain free by end of study (day 6) compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 days
RR 2.00 [1.39, 2.89]
1 study · 100 participants
GRADE not reported

Er:YAG laser debridement vs Manual debridement plus chlorhexidine irrigation/gel

Complications and side effects · People with at least one dental implant affected by perimplantitis

Er:YAG laser debridement led to lower complications and side effects compared with manual debridement plus chlorhexidine irrigation/gel; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes
6 months
Complications: risk ratio (totals not selected); one laser patient had a buccal keratinised mucosa perforation.
1 study · 20 participants
GRADE not reported

Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste

Investigator‐ or physician‐rated global assessment of disease severity · People with erosive oral lichen planus

Betamethasone oral mini-pulse therapy led to higher physician Global Assessment (clinical severity, 0-12 score) compared with topical triamcinolone acetonide 0.1% paste; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
24 weeks
MD 1.78 [0.17, 3.39]
1 study · 22 participants
GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Hegarty 2002: nausea (4), swollen mouth (1), bad taste and smell (6), difficulty in spray application (7), dry mouth (2), sore throat (1), red painful tongue (1), and pseudomembranous…
1 study · 44 participants
GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

Sugar intake frequency between meals (mean number of intakes per day) · Adults with frequent sugar intake harbouring Streptococcus mutans and Streptococcus sobrinus in saliva (14 dental technical students and 6…

1 finding from 1 review

One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes
Follow-up at 3, 6 and 12 weeks
Table 5, mean (SD) intakes/day between meals: intervention 6.7 (1.9) baseline, 0.8 (1.0) at 3 weeks, 0.9 (1.0) at 6 weeks, 5.6 (3.0) at 12 weeks; control 5.3 (2.3), 5.2 (2.9), 4.6 (3.5), 4.7 (1.5). Significant…
1 study · 20 participants
GRADE not reported

Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline

Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

Sodium hypochlorite 5.25% with hydrogen peroxide 3% showed no clear difference in proportion of participants with moderate to severe pain 72 hours to… compared with normal saline; GRADE not reported.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
RR 0.65 [0.2, 2.0]
1 study · 161 participants
GRADE not reported

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Eating warm meals more than twice per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland

1 finding from 1 review

One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes
2 to 4 years
Table 2: 77% (193) versus 81% (200) at follow-up (baseline 83% versus 74%, a significant baseline difference). No significant change at follow-up.
1 study · 497 participants
GRADE not reported

Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite 5.25% vs Normal saline

Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Flapless implant placement vs Conventional flap elevation

Patient preference · People with dental implants

Flapless implant placement led to higher patient preference compared with conventional flap elevation; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: management of soft tissues for dental implants 2012 · Cochrane All outcomes
RR 106.70 [20.97, 542.82]
1 study · 80 participants
GRADE not reported

Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3%

Change in periapical radiolucency (radiography or CBCT), up to 1 year after treatment · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Leukotriene receptor antagonist vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
2 months
The study reported equal drug-related adverse effects for those treated with montelukast and placebo.
1 study · 40 participants
GRADE not reported

Glucosamine sulfate (oral) vs ibuprofen

Pain-free maximum jaw opening (mm), change from baseline · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) showed no clear difference in pain-free maximum jaw opening (mm), change from baseline compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review

Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
90 days
MD 1.75 [-4.10, 7.60]
1 study · 45 participants
GRADE not reported

Sodium hypochlorite 1% with chlorhexidine 2% final rinse vs Sodium hypochlorite 1% with normal saline final rinse

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Titanium framework FDP vs High-gold content alloy framework FDP

5-year prosthesis survival · Partially edentulous patients receiving tooth-supported FDPs

1 finding from 1 review

Interventions for replacing missing teeth: partially absent dentition 2012 · Cochrane All outcomes
5 years
5-year prosthesis survival 84% (95% CI 0.79 to 0.89) titanium vs 98% (95% CI 0.96 to 1.00) high-gold alloy; statistically significant difference (P = 0.005)
1 study · 47 participants
GRADE not reported