What do systematic reviews say?

492 questions · 535 findings · 56 reviews · Hypertension

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No studies found 37 · 6.9%GRADE not reported 34 · 6.4%Very low 91 · 17%Low 161 · 30.1%Moderate 136 · 25.4%High 76 · 14.2%

Higher BP target (< 150‐160/95‐105 mmHg) vs lower BP target (< 140/90 mmHg)

Withdrawals due to adverse events · older adults with primary hypertension

Higher BP target (< 150‐160/95‐105 mmHg) showed no clear difference in withdrawals due to adverse effects compared with lower BP target (< 140/90 mmHg) (low certainty).

1 finding from 1 review

Blood pressure targets for hypertension in older adults 2017 · Cochrane Headline outcomes only
RR 0.83 [0.58, 1.19]
2 studies · 7497 participants
Low

Intervention not reported

End of treatment SBP (over 12 weeks) · patients with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 50 participants
Moderate

Intervention not reported

End of treatment DBP (over 12 weeks) · patients with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 50 participants
Moderate

Intervention not reported

Withdrawals due to adverse effects · patients with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
GRADE not reported

Intervention not reported

Systolic blood pressure · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
47 studies · 5246 participants
Low

Intervention not reported

Diastolic blood pressure · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
48 studies · 5316 participants
Low

Intervention not reported

Heart rate · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
33 studies · 3407 participants
Low

Intervention not reported

Pulse pressure · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
47 studies · 5246 participants
Very low

Intervention not reported

WDAE · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 2618 participants
Low

Antihypertensive pharmacotherapy vs control

Sudden cardiac death · patients with hypertension

Antihypertensive pharmacotherapy showed no clear difference in sudden cardiac death ( compared with control (moderate certainty).

1 finding from 1 review

Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals 2016 · Cochrane Headline outcomes only
RR 0.96 [0.81, 1.15]
15 studies · 39908 participants
Moderate

Antihypertensive pharmacotherapy vs control

Non‐fatal MI · patients with hypertension

Antihypertensive pharmacotherapy probably leads to lower non‐fatal myocardial infarction ( compared with control (moderate certainty).

1 finding from 1 review

Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals 2016 · Cochrane Headline outcomes only
RR 0.85 [0.74, 0.98]
15 studies · 39908 participants
Moderate

Antihypertensive pharmacotherapy vs control

Fatal myocardial infarction ( · patients with hypertension

Antihypertensive pharmacotherapy probably leads to lower fatal myocardial infarction ( compared with control (moderate certainty).

1 finding from 1 review

Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals 2016 · Cochrane Headline outcomes only
RR 0.75 [0.62, 0.9]
15 studies · 39908 participants
Moderate

Intervention not reported

Decrease in SBP mmHg mean duration 8.8 weeks · People with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of loop diuretics for primary hypertension 2015 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 460 participants
Low

Intervention not reported

Decrease in DBP mmHg mean duration 8.8 weeks · People with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of loop diuretics for primary hypertension 2015 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 460 participants
Low

Intervention not reported

Systolic blood pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension 2015 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1007 participants
Low

Intervention not reported

Diastolic blood pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension 2015 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1007 participants
Low

Intervention not reported

Heart rate · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension 2015 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 977 participants
Low

Intervention not reported

Pulse pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension 2015 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1007 participants
Very low

Intervention not reported

WDAE · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1412 participants
Moderate

Intervention not reported

LDL‐cholesterol atorvastatin 10 mg/d · individuals with normal or abnormal lipid profiles

1 finding from 1 review

Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
no estimate extracted
188 studies · 21941 participants
High