Incidence of eruption of the PDC into the mouth · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
It is very uncertain whether extraction of the primary (baby) canine (single primary tooth… changes incidence of eruption of the PDC into the mouth compared with no extraction (non-intervention control) (very low certainty).
1 finding from 1 review
Costs and cost‐effectiveness · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
The review found no eligible studies for this question.
1 finding from 1 review
Patient-reported outcomes (pain, discomfort and analgesic use) · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
1 finding from 1 review
Self-reported VAS pain (Naoumova 2012): pain and discomfort from extraction of the primary canine were low both during and after the procedure and mostly absent at one week; 35% of boys and 50% of girls took one dose…
1 study · 44 participants
GRADE not reported
Reported improvement in the position of the ectopic canine measured from radiographs · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Patient‐reported outcome measures (PROMs) · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Any other adverse effects of the interventions, such as gingival disease and demineralisation · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
The review found no eligible studies for this question.
1 finding from 1 review
Incidence of successfully erupted PDC that were favourably positioned · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
The review found no eligible studies for this question.
1 finding from 1 review
Overall treatment time wearing orthodontic appliances · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Costs and cost‐effectiveness · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
The review found no eligible studies for this question.
1 finding from 1 review
Time taken for the canine to erupt into the mouth · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Overall treatment time wearing orthodontic appliances · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Percentage of closed pockets · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Azithromycin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD -0.57 [-1.08, -0.07]
6 studies · 216 participants
GRADE not reported
MD -0.77 [-2.33, 0.79]
2 studies · 110 participants
Very low
MD -0.60 [-1.02, -0.18]
7 studies · 258 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.34 [-0.08, 0.76]
3 studies · 75 participants
GRADE not reported
MD 1.10 [0.36, 1.84]
1 study · 27 participants
Very low
MD -0.12 [-0.72, 0.49]
2 studies · 49 participants
GRADE not reported
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether metronidazole + SRP changes probing pocket depth compared with SRP (very low certainty).
3 findings from 1 review
MD -1.11 [-2.84, 0.61]
2 studies · 47 participants
Very low
MD -0.59 [-0.95, -0.23]
4 studies · 94 participants
GRADE not reported
MD -0.10 [-0.37, 0.16]
4 studies · 108 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.80 [-1.49, -0.11]
1 study · 22 participants
Very low
MD -0.61 [-1.14, -0.08]
3 studies · 65 participants
GRADE not reported
MD 0.15 [-0.53, 0.83]
2 studies · 43 participants
GRADE not reported
Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)
Azithromycin + SRP showed no clear difference in percentage of closed pockets compared with SRP; GRADE not reported.
2 findings from 1 review
Probing pocket depth · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.10 [-0.29, 0.50]
2 studies · 43 participants
GRADE not reported
MD -1.00 [-1.78, -0.22]
1 study · 22 participants
Very low
MD -0.43 [-0.88, 0.01]
3 studies · 65 participants
GRADE not reported
Patient-reported quality of life changes · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Trismus / maximum mouth opening (mean) · Adults with mandibular third molars requiring removal
Fibrin sealant led to higher trismus / maximum mouth opening (mean) compared with conventional suturing; GRADE not reported.
1 finding from 1 review