Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

508 questions · 529 findings · 58 reviews

No studies found 191 · 36.1%GRADE not reported 49 · 9.3%Very low 143 · 27%Low 92 · 17.4%Moderate 51 · 9.6%High 3 · 0.6%

NMA evidence for individual network: proportion with complete healing ‐ interventions vs saline gauze

Hydrocolloid dressing with/without alginate · people with pressure ulcers

It is very uncertain whether NMA evidence for individual network: proportion with complete… changes hydrocolloid dressing with/without alginate compared with saline gauze (very low certainty).

1 finding from 1 review

Silicone‐filled vs saline‐filled implants

Capsular contracture Number of women with capsular contracture · women having reconstructive breast surgery

It is very uncertain whether silicone‐filled changes capsular contracture Number of women with capsular contracture compared with saline‐filled implants (very low certainty).

1 finding from 1 review

Silicone‐filled vs saline‐filled implants

Patient satisfaction for consistency Number of women satisfied · women having reconstructive breast surgery

It is very uncertain whether silicone‐filled changes patient satisfaction for consistency Number of women satisfied compared with saline‐filled implants (very low certainty).

1 finding from 1 review

PVP‐hydrogel‐filled vs saline‐filled implants

Capsular contracture Number of women with capsular contracture · women having reconstructive breast surgery

It is very uncertain whether PVP‐hydrogel‐filled changes capsular contracture Number of women with capsular contracture compared with saline‐filled implants (very low certainty).

1 finding from 1 review

PVP‐hydrogel‐filled vs saline‐filled implants

Short‐term complications Number of women with at least one short‐term complication · women having reconstructive breast surgery

It is very uncertain whether PVP‐hydrogel‐filled changes short‐term complications Number of women with at least one… compared with saline‐filled implants (very low certainty).

1 finding from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Oral mucositis (severe) · All patients with cancer who are receiving treatment

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… probably leads to lower oral mucositis (severe) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (moderate certainty).

3 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Number of days of treatment with opioid analgesics · All patients with cancer who are receiving treatment

The review found no eligible studies for this question.

2 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Quality of life · All patients with cancer who are receiving treatment
2 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Adverse events · All patients with cancer who are receiving treatment
2 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Oral mucositis (mean severity on WHO 0 to 4 scale) · All patients with cancer who are receiving treatment

It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (mean severity on WHO 0 to 4 scale) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (very low certainty).

1 finding from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Oral pain · All patients with cancer who are receiving treatment
3 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Oral mucositis (any severity) · All patients with cancer who are receiving treatment

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… showed no clear difference in oral mucositis (any severity) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (low certainty).

3 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Number of days in hospital (duration of hospitalisation) · All patients with cancer who are receiving treatment

The review found no eligible studies for this question.

2 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Oral mucositis (moderate to severe) · All patients with cancer who are receiving treatment

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… showed no clear difference in oral mucositis (moderate to severe) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (low certainty).

3 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Interruptions to cancer treatment (incidence) · All patients with cancer who are receiving treatment

The review found no eligible studies for this question.

2 findings from 1 review