Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

564 questions · 589 findings · 155 reviews · Headline outcomes only

No studies found 114 · 19.4%GRADE not reported 15 · 2.5%Very low 179 · 30.4%Low 141 · 23.9%Moderate 110 · 18.7%High 30 · 5.1%

Psychological therapy vs enhanced or structured care

Secondary outcome: acceptability of treatment · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy showed no clear difference in acceptability 1 ‐ proportion of participants withdrawing during… compared with enhanced or structured care (moderate certainty).

1 finding from 1 review

Personalised risk communication vs general risk information

Uptake of screening test ‐ Numerical and categorised risk combined Number of participants taking up the test · patients with informed decision making about taking screening tests

Personalised risk communication may leads to higher uptake of screening test ‐ Numerical and categorised risk combined… compared with general risk information (low certainty).

1 finding from 1 review

Exercise vs control

Secondary outcome: acceptability of treatment · depression in adults
1 finding from 1 review
  • Exercise for depression 2013 · Cochrane Headline outcomes only
    no estimate extracted
    29 studies · 1363 participants
    Moderate

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Acceptability (number of participants lost to post‐treatment assessment) · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes treatment acceptability at post‐treatment Dropout rates compared with other psychological therapies (very low certainty).

1 finding from 1 review

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Secondary outcome: acceptability of treatment · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes treatment acceptability at compared with other psychological therapies (very low certainty).

1 finding from 1 review

Intervention not reported

Acceptability end of treatment (dropouts from study due to any reasons) · Patients with fibromyalgia

The intervention showed no clear difference in acceptability end of treatment (dropouts from study due to any… (low certainty).

1 finding from 1 review

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes leaving the study early due to any reason (overall acceptability of… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

BENZODIAZEPINES AS SOLE TREATMENT vs placebo

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES AS SOLE TREATMENT changes leaving the study early due to any reason (overall acceptability of… compared with PLACEBO (very low certainty).

1 finding from 1 review

Benzodiazepines vs antipsychotics

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to any reason (overall acceptability of… compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Knee length vs compression stockings

Deep vein thrombosis · patients with prevention of deep vein thrombosis1

It is very uncertain whether knee length changes deep vein thrombosis (Fixed‐effect analysis) Venous duplex scan,… compared with thigh length graduated compression stockings (very low certainty).

3 findings from 1 review

Intervention not reported

Acceptability · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)
1 finding from 1 review

Amitriptyline vs placebo

Acceptability of treatment Drop‐out for any reason · adults with Major Depressive Disorder

It is very uncertain whether amitriptyline changes acceptability of treatment Drop‐out for any reason compared with placebo (very low certainty).

1 finding from 1 review

Local anaesthetic injection vs no treatment/placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · septal surgery

The review found no eligible studies for this question.

3 findings from 1 review

Local anaesthetic application via nasal packing vs no packing/packing with placebo

Additional analgesia required (escape analgesia) · septal surgery

Local anaesthetic application via nasal packing probably leads to lower requirement for additional analgesia compared with no packing/packing with placebo (moderate certainty).

1 finding from 1 review