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Evidence found and GRADE certainty

1,156 questions · 1,179 findings · 198 reviews · Headline outcomes only

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No studies found 250 · 21.2%GRADE not reported 43 · 3.6%Very low 236 · 20%Low 395 · 33.5%Moderate 208 · 17.6%High 47 · 4%

Zuclopenthixol dihydrochloride vs RISPERIDONE

Adverse effects: Clinically important general adverse effect ‐ short term (EPSEs requiring medication) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect ‐ short… compared with risperidone (very low certainty).

1 finding from 1 review

Neuroprotection vs control

Adverse effects: ocular allergy to the study medication requiring discontinuation up to 4 years' · people with open‐angle glaucoma

It is very uncertain whether neuroprotection changes adverse effects: ocular allergy to the study medication requiring… compared with control (very low certainty).

1 finding from 1 review

Intervention not reported

New/intensified lipid‐lowering medication · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)

The intervention may leads to higher new/intensified lipid‐lowering medication (low certainty).

1 finding from 1 review

Intervention not reported

New/intensified antihypertensive medication · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)

The intervention may leads to higher new/intensified antihypertensive medication (low certainty).

1 finding from 1 review

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) vs MEDIUM DOSE (401 mg/day to 800 mg/day)

Global state: needing additional medication (sedation with chloral hydrate or a barbiturate > 5 times) ‐ medium term · patients with schizophrenia

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) showed no clear difference in global state: needing additional medication (sedation with chloral… compared with MEDIUM DOSE (401 mg/day to 800 mg/day) (low certainty).

1 finding from 1 review

Intervention not reported

Number of participants who had additional self‐medication · Women undergoing excision of the cervical transformation zone for cervical neoplasia

It is very uncertain whether the intervention changes number of participants who had additional self‐medication (very low certainty).

1 finding from 1 review

Intervention not reported

Premedication given ‐ no premedication given: first intubation attempt success rate (outcome achieved at time of intubation attempt and not followed up) · neonates requiring endotracheal intubation

The intervention showed no clear difference in premedication given ‐ no premedication given: first intubation… (moderate certainty).

1 finding from 1 review