Withdrawals due to any reason · patients with chronic asthma
LABA + ICS probably leads to lower withdrawals for any reason compared with LTRA + ICS (moderate certainty).
1 finding from 1 review
Serious adverse events · patients with chronic asthma
LABA + ICS showed no clear difference in serious adverse events compared with LTRA + ICS (moderate certainty).
1 finding from 1 review
Intervention not reported
Linear growth velocity in first year of treatment (cm/y) · children up to 18 years of age with persistent asthma
1 finding from 1 review
Intervention not reported
Change from baseline in height over first year of treatment (cm) · children up to 18 years of age with persistent asthma
1 finding from 1 review
Intervention not reported
Change in height standard deviation score (SDS) in first year of treatment · children up to 18 years of age with persistent asthma
1 finding from 1 review
Intervention not reported
Growth velocity over 12 months (cm/y) (higher is better) · children with persistent asthma
The intervention leads to higher growth velocity over 12 months (cm/y) (higher is better) (high certainty).
1 finding from 1 review
Intervention not reported
Change in height over 3 months (cm) (higher is better) · children with persistent asthma
The intervention showed no clear difference in change in height over 3 months (cm) (higher is better) (moderate certainty).
1 finding from 1 review
Intervention not reported
Change in height over 12 months (cm) (higher is better) · children with persistent asthma
The intervention showed no clear difference in change in height over 12 months (cm) (higher is better) (moderate certainty).
1 finding from 1 review
Intervention not reported
Change in SD scores over 12 months (height) (low change is better) · children with persistent asthma
The intervention showed no clear difference in change in SD scores over 12 months (height) (low change is better) (moderate certainty).
1 finding from 1 review
Intervention not reported
Change in weight over 12 months (kg) (higher is better) · children with persistent asthma
The intervention showed no clear difference in change in weight over 12 months (kg) (higher is better) (low certainty).
1 finding from 1 review
Intervention not reported
Change in BMI over 12 months (kg/m2) (higher is better) · children with persistent asthma
The intervention showed no clear difference in change in BMI over 12 months (kg/m2) (higher is better) (low certainty).
1 finding from 1 review
Intervention not reported
Change in skeletal maturation over 12 months (years) (higher is better) · children with persistent asthma
The intervention may leads to higher change in skeletal maturation over 12 months (years) (higher is… (low certainty).
1 finding from 1 review
Intervention not reported
Outcomes · patients with chronic obstructive pulmonary disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Mortality, all‐cause · patients with chronic obstructive pulmonary disease
The intervention showed no clear difference in mortality, all‐cause (moderate certainty).
1 finding from 1 review
Intervention not reported
Mortality, due to pneumonia · patients with chronic obstructive pulmonary disease
It is very uncertain whether the intervention changes mortality, due to pneumonia (very low certainty).
1 finding from 1 review
Intervention not reported
Non‐fatal, serious adverse events (all) · patients with chronic obstructive pulmonary disease
The intervention showed no clear difference in non‐fatal, serious adverse events (all) (moderate certainty).
1 finding from 1 review
Intervention not reported
All pneumonia events · patients with chronic obstructive pulmonary disease
The intervention showed no clear difference in all pneumonia events (moderate certainty).
1 finding from 1 review
Intervention not reported
Withdrawals · patients with chronic obstructive pulmonary disease
The intervention leads to lower withdrawals (high certainty).
1 finding from 1 review
Intervention not reported
Non‐fatal, serious adverse pneumonia events (requiring hospital admission) · patients with chronic obstructive pulmonary disease
The intervention leads to higher non‐fatal, serious adverse pneumonia events (requiring hospital… (high certainty).
1 finding from 1 review
Intervention not reported
Mortality, all‐cause · patients with chronic obstructive pulmonary disease
The intervention showed no clear difference in mortality, all‐cause (high certainty).
1 finding from 1 review