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What do systematic reviews say?

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Evidence found and GRADE certainty

406 questions · 416 findings · 20 reviews · Common Mental Disorders

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No studies found 73 · 17.5%GRADE not reported 9 · 2.2%Very low 144 · 34.6%Low 123 · 29.6%Moderate 59 · 14.2%High 8 · 1.9%

Second generation antidepressant vs placebo medication

Remission or response (as defined in trial) · patients with depressive disorders in children and adolescents

Second generation antidepressant probably leads to higher remission or response (as defined in trial) compared with placebo (by medication) (moderate certainty).

1 finding from 1 review

Second generation antidepressant vs placebo medication

Suicide‐related outcomes Timing of outcome assessment: end of treatment (6 to 12 weeks treatment duration) · patients with depressive disorders in children and adolescents

Second generation antidepressant may leads to higher suicide‐related outcome compared with placebo (by medication) (low certainty).

1 finding from 1 review