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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

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No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Summary of findings: lorazepam plus haloperidol vs placebo plus haloperidol

Specific behaviour ‐ agitation · terminally ill adults with severe delirium

It is very uncertain whether summary of findings: lorazepam plus haloperidol changes agitation within 24 hoursc compared with placebo plus haloperidol (very low certainty).

2 findings from 1 review

Summary of findings: lorazepam plus haloperidol vs placebo plus haloperidol

Adverse events including extrapyramidal effects · terminally ill adults with severe delirium

It is very uncertain whether summary of findings: lorazepam plus haloperidol changes adverse events including extrapyramidal effectsd compared with placebo plus haloperidol (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes symptoms of delirium between 24 and 48 hoursa compared with chlorpromazine (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Adverse events including extrapyramidal effects · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes adverse events including extrapyramidal effectsc compared with chlorpromazine (very low certainty).

1 finding from 1 review

HALOPERIDOL vs lorazepam

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes symptoms of delirium between 24 and 48 hoursa compared with lorazepam (very low certainty).

1 finding from 1 review

HALOPERIDOL vs lorazepam

Adverse events including extrapyramidal effects · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes adverse events including extrapyramidal effectsc compared with lorazepam (very low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Adverse events including extrapyramidal effects · terminally ill adults with delirium

Summary of findings: haloperidol showed no clear difference in adverse events including extrapyramidal effectse compared with placebo (moderate certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Symptoms of delirium within 24 hoursa · terminally ill adults with delirium

Summary of findings: haloperidol showed no clear difference in symptoms of delirium within 24 hoursa compared with risperidone (low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

Summary of findings: haloperidol showed no clear difference in symptoms of delirium between 24 and 48 hoursa compared with risperidone (low certainty).

1 finding from 1 review