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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,518 questions in 135 reviews · Infectious Diseases
current versionsNo studies 135 · 8.9%Ungraded 150 · 9.9%Very low 350 · 23.1%Low 420 · 27.7%Moderate 321 · 21.1%High 142 · 9.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mefloquine vs atovaquone‐proguanil Anxiety · non‐immune adults and children travelling to or living in malaria‐endemic settings Mefloquine for preventing malaria during travel to endemic areas (2017) · Cochrane | RR 6.12 [1.82, 20.66] | 1 study · 976 participants | Ungraded |
Mefloquine vs atovaquone‐proguanil Depressed mood · non‐immune adults and children travelling to or living in malaria‐endemic settings Mefloquine for preventing malaria during travel to endemic areas (2017) · Cochrane | RR 5.78 [1.71, 19.61] | 1 study · 976 participants | Ungraded |
Mefloquine vs atovaquone‐proguanil Abnormal thoughts or perceptions · non‐immune adults and children travelling to or living in malaria‐endemic settings Mefloquine for preventing malaria during travel to endemic areas (2017) · Cochrane | RR 1.5 [0.3, 7.42] | 3 studies · 2433 participants | Ungraded |
Mefloquine vs atovaquone‐proguanil Nausea · non‐immune adults and children travelling to or living in malaria‐endemic settings Mefloquine for preventing malaria during travel to endemic areas (2017) · Cochrane | RR 2.72 [1.52, 4.86] | 1 study · 976 participants | Ungraded |
Intervention NR Clinical malaria (incidence) · people living in malaria‐endemic areas Larvivorous fish for preventing malaria transmission (2017) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Entomological inoculation rate · people living in malaria‐endemic areas Larvivorous fish for preventing malaria transmission (2017) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Density of adult malaria vectors · people living in malaria‐endemic areas Larvivorous fish for preventing malaria transmission (2017) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Density of immature vector stages in water bodies Quasi‐experimental studies · people living in malaria‐endemic areas Larvivorous fish for preventing malaria transmission (2017) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR Larval sites positive for immature vector stages Quasi‐experimental studies · people living in malaria‐endemic areas Larvivorous fish for preventing malaria transmission (2017) · Cochrane | no estimate extracted | NR | Low |
Intervention NR All‐cause mortality · HIV‐positive adults Interleukin‐2 as an adjunct to antiretroviral therapy for HIV‐positive adults (2017) · Cochrane | RR 0.97 [0.8, 1.17] | 6 studies · 6565 participants | High |
Intervention NR CD4 cell count · HIV‐positive adults Interleukin‐2 as an adjunct to antiretroviral therapy for HIV‐positive adults (2017) · Cochrane | no estimate extracted | 21 studies · 7600 participants | Ungraded |
Intervention NR HIV RNA levels less than 50 cells/mL · HIV‐positive adults Interleukin‐2 as an adjunct to antiretroviral therapy for HIV‐positive adults (2017) · Cochrane | RR 0.97 [0.81, 1.15] | 5 studies · 805 participants | High |
Intervention NR HIV RNA levels less than 500 cells/mL · HIV‐positive adults Interleukin‐2 as an adjunct to antiretroviral therapy for HIV‐positive adults (2017) · Cochrane | RR 0.96 [0.82, 1.12] | 4 studies · 5929 participants | High |
Intervention NR Opportunistic infections · HIV‐positive adults Interleukin‐2 as an adjunct to antiretroviral therapy for HIV‐positive adults (2017) · Cochrane | RR 0.79 [0.55, 1.13] | 7 studies · 6141 participants | Low |
Intervention NR Adverse events (grade 3 or 4) · HIV‐positive adults Interleukin‐2 as an adjunct to antiretroviral therapy for HIV‐positive adults (2017) · Cochrane | RR 1.47 [1.1, 1.96] | 6 studies · 6291 participants | Moderate |
Intervention NR Depression score · adults living with HIV Psychosocial group interventions to improve psychological well‐being in adults living with HIV (2017) · Cochrane | no estimate extracted | 10 studies · 1139 participants | Low |
Intervention NR Anxiety score · adults living with HIV Psychosocial group interventions to improve psychological well‐being in adults living with HIV (2017) · Cochrane | no estimate extracted | 4 studies · 471 participants | Low |
Intervention NR Stress score · adults living with HIV Psychosocial group interventions to improve psychological well‐being in adults living with HIV (2017) · Cochrane | no estimate extracted | 5 studies · 507 participants | Low |
Intervention NR Coping score · adults living with HIV Psychosocial group interventions to improve psychological well‐being in adults living with HIV (2017) · Cochrane | no estimate extracted | 5 studies · 697 participants | Low |
Intervention NR Depression score · adults living with HIV Psychosocial group interventions to improve psychological well‐being in adults living with HIV (2017) · Cochrane | no estimate extracted | 3 studies · 233 participants | Very low |
Intervention NR Anxiety score · adults living with HIV Psychosocial group interventions to improve psychological well‐being in adults living with HIV (2017) · Cochrane | no estimate extracted | 2 studies · 162 participants | Very low |
Intervention NR Stress score · adults living with HIV Psychosocial group interventions to improve psychological well‐being in adults living with HIV (2017) · Cochrane | no estimate extracted | 2 studies · 137 participants | Very low |
Intervention NR Coping score · adults living with HIV Psychosocial group interventions to improve psychological well‐being in adults living with HIV (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Tuberculosis outreach screening vs no intervention Tuberculosis cases detected (microbiologically confirmed) · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | RR 1.24 [0.86, 1.79] | 4 studies · 163043 participants | Low |
Health promotion activities vs no intervention Long‐term tuberculosis prevalence · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | NR | No studies |
Training interventions vs no intervention Tuberculosis cases detected (microbiologically confirmed) · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | RR 1.68 [1.03, 2.72] | 1 study · 1999 participants | Low |
Training interventions vs no intervention Treatment success · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Training interventions vs no intervention Tuberculosis mortality · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Training interventions vs no intervention Long‐term tuberculosis prevalence · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Outreach tuberculosis screening vs health promotion Tuberculosis cases detected (microbiologically confirmed) · adults Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | RR 1.71 [1.27, 2.31] | 1 study · 110162 participants | Very low |
Outreach tuberculosis screening vs health promotion Treatment success · adults Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Outreach tuberculosis screening vs health promotion Tuberculosis mortality · adults Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Outreach tuberculosis screening vs health promotion Long‐term tuberculosis prevalence · adults Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Outreach clinic vs house‐to‐house screening Tuberculosis cases detected (microbiologically confirmed) · adults Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | RR 1.48 [1.11, 1.97] | 1 study · 405819 participants | Very low |
Tuberculosis outreach screening vs no intervention Default within first 2 months · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | RR 0.67 [0.47, 0.96] | 849 participants | Low |
Outreach clinic vs house‐to‐house screening Treatment success · adults Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Outreach clinic vs house‐to‐house screening Tuberculosis mortality · adults Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Outreach clinic vs house‐to‐house screening Long‐term tuberculosis prevalence · adults Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Tuberculosis outreach screening vs no intervention Treatment success · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | RR 1.07 [1, 1.15] | 849 participants | Low |
Tuberculosis outreach screening vs no intervention Treatment failure · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | RR 1.57 [0.5, 4.92] | 849 participants | Very low |
Tuberculosis outreach screening vs no intervention Tuberculosis mortality · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | RR 0.99 [0.43, 2.25] | 849 participants | Low |
Tuberculosis outreach screening vs no intervention Long‐term tuberculosis prevalence · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | RR 1.14 [0.65, 2] | 556836 participants | Very low |
Health promotion activities vs no intervention Long‐term tuberculosis prevalence (assessed at 4 years) · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | RR 1.31 | 405788 participants | Very low |
Health promotion activities vs no intervention Treatment success · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | NR | No studies |
Health promotion activities vs no intervention Tuberculosis mortality · all age groups Interventions to increase tuberculosis case detection at primary healthcare or community‐level services (2017) · Cochrane | no estimate extracted | NR | No studies |
Any corticosteroid vs control Death · adults or children with tuberculous meningitis on tuberculosis (TB) chemotherapy Corticosteroids for managing tuberculous meningitis (2016) · Cochrane | RR 0.75 [0.65, 0.87] | 9 studies · 1337 participants | High |
Any corticosteroid vs control Disabling neurological deficit · adults or children with tuberculous meningitis on tuberculosis (TB) chemotherapy Corticosteroids for managing tuberculous meningitis (2016) · Cochrane | RR 0.92 [0.71, 1.2] | 8 studies · 1314 participants | Low |
Intervention NR Virological success · antiretroviral‐naïve individuals Efavirenz or nevirapine in three‐drug combination therapy with two nucleoside or nucleotide‐reverse… (2016) · Cochrane | RR 1.04 [0.99, 1.09] | 10 studies · 2438 participants | High |
Intervention NR Severe adverse events: pyrexia · antiretroviral‐naïve individuals Efavirenz or nevirapine in three‐drug combination therapy with two nucleoside or nucleotide‐reverse… (2016) · Cochrane | RR 0.65 [0.15, 2.73] | 3 studies · 1799 participants | Low |
Intervention NR Severe adverse events: raised transaminases · antiretroviral‐naïve individuals Efavirenz or nevirapine in three‐drug combination therapy with two nucleoside or nucleotide‐reverse… (2016) · Cochrane | RR 0.52 [0.35, 0.78] | 3 studies · 1299 participants | High |