Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,171 questions · 1,373 findings · 60 reviews · Dental caries

No studies found 282 · 20.5%GRADE not reported 606 · 44.1%Very low 257 · 18.7%Low 160 · 11.7%Moderate 66 · 4.8%High 2 · 0.1%

2400 to 2800 ppm F toothpaste vs 1700 to 2200 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

It is very uncertain whether 2400 to 2800 ppm F toothpaste changes caries increment, tooth index D(M)FT compared with 1700 to 2200 ppm F toothpaste (very low certainty).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

It is very uncertain whether 1700 to 2200 ppm F toothpaste changes caries increment, tooth index D(M)FT compared with 1000 to 1250 ppm F toothpaste (very low certainty).

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 1000 to 1250 ppm F toothpaste (low certainty).

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Postoperative hypersensitivity (POH), cold response measurement (time in seconds) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth

Dental cavity liner (e.g. calcium hydroxide, glass ionomer,… may leads to higher postoperative hypersensitivity (POH), cold response measurement… compared with no liner (resin-based composite bonded directly to the tooth) (low certainty).

1 finding from 1 review

Rubber/elastomeric cleaning stick plus toothbrushing vs Flossing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether rubber/elastomeric cleaning stick plus toothbrushing changes gingivitis (gingival index) compared with flossing plus toothbrushing (very low certainty).

2 findings from 1 review

Wooden cleaning stick plus toothbrushing vs Toothbrushing alone

Gingivitis · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

2 findings from 1 review

Interdental brushing plus toothbrushing vs Toothbrushing alone

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether interdental brushing plus toothbrushing changes gingivitis (gingival index) compared with toothbrushing alone (very low certainty).

3 findings from 2 reviews · compare the 2 reviews

Oral irrigation plus toothbrushing vs Flossing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether oral irrigation plus toothbrushing changes gingivitis (gingival index) compared with flossing plus toothbrushing (very low certainty).

2 findings from 1 review

1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste

Proportion developing new caries · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)

1055 to 1100 ppm F toothpaste may leads to lower proportion developing new caries compared with 500 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste probably leads to lower caries increment, tooth index D(M)FT compared with non-fluoride (0 ppm F) placebo toothpaste (moderate certainty).

1 finding from 1 review

Interdental brushing plus toothbrushing vs Toothbrushing alone

Plaque · Adults, 16 years and older (dentate)

Interdental brushing plus toothbrushing may leads to lower plaque compared with toothbrushing alone (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Oral irrigation plus toothbrushing vs Toothbrushing alone

Periodontitis (probing pocket depth) · Adults, 16 years and older (dentate)
1 finding from 1 review

Patient-used 5000 ppm F toothpaste, daily vs 1450 to 1500 ppm F toothpaste

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste may leads to lower caries increment, tooth index D(M)FT compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).

1 finding from 1 review

Oral irrigation plus toothbrushing vs Toothbrushing alone

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether oral irrigation plus toothbrushing changes gingivitis (gingival index) compared with toothbrushing alone (very low certainty).

2 findings from 1 review

1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily vs 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste probably leads to lower caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (moderate certainty).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste may leads to lower caries increment, tooth index D(M)FT compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).

1 finding from 1 review