What do systematic reviews say?

Summary of findings: insulin detemir vs Insulin glargin (control)

Insulin detemir (intervention) may leads to higher percentage of participants having at least one injection site reaction compared with insulin glargin (control) (low certainty).

• Insulin detemir versus insulin glargine for type 2 diabetes mellitus 2011 · Cochrane Headline outcomes only
  RR 3.31 [1.13, 9.73]
  4 studies · 2252 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Acupuncture for peripheral joint osteoarthritis 2010 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Acupuncture for peripheral joint osteoarthritis 2010 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

CHLORPROMAZINE vs haloperidol

It is very uncertain whether CHLORPROMAZINE changes global outcome: Number of additional injections ‐ 2‐4 injections compared with HALOPERIDOL (very low certainty).

• Chlorpromazine for psychosis induced aggression or agitation 2010 · Cochrane Headline outcomes only
  RR 0.9 [0.52, 1.55]
  1 study · 30 participants
  Very low

CHLORPROMAZINE vs haloperidol

It is very uncertain whether CHLORPROMAZINE changes global outcome: Number of additional injections ‐ 5 or more compared with HALOPERIDOL (very low certainty).

• Chlorpromazine for psychosis induced aggression or agitation 2010 · Cochrane Headline outcomes only
  RR 0.75 [0.2, 2.79]
  1 study · 30 participants
  Very low

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

• Continuous infusion versus bolus injection of loop diuretics for acute heart failure 2024 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 169 participants
  Very low

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

• Continuous infusion versus bolus injection of loop diuretics for acute heart failure 2024 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 497 participants
  Very low

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in all‐cause mortality (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

• Continuous infusion versus bolus injection of loop diuretics for acute heart failure 2024 · Cochrane Headline outcomes only
  RR 1.53 [0.81, 2.9]
  5 studies · 530 participants
  Low

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

The review found no eligible studies for this question.

• Continuous infusion versus bolus injection of loop diuretics for acute heart failure 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

• Continuous infusion versus bolus injection of loop diuretics for acute heart failure 2024 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 211 participants
  Very low

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in readmission to hospital following discharge compared with bolus injection of intravenous loop diuretics (low certainty).

• Continuous infusion versus bolus injection of loop diuretics for acute heart failure 2024 · Cochrane Headline outcomes only
  RR 0.85 [0.63, 1.16]
  3 studies · 400 participants
  Low

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in acute kidney injury (adverse event) (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

• Continuous infusion versus bolus injection of loop diuretics for acute heart failure 2024 · Cochrane Headline outcomes only
  RR 1.02 [0.7, 1.49]
  3 studies · 491 participants
  Low

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) showed no clear difference in cumulative live birth compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.95 [0.82, 1.1]
  4 studies · 985 participants
  Low

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 0.13 [0.08, 0.21]
  4 studies · 985 participants
  Moderate

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) showed no clear difference in clinical pregnancy rate compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.95 [0.84, 1.08]
  3 studies · 943 participants
  Low

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 2.14 [0.93, 4.95]
  2 studies · 282 participants
  Low

Single vs multiple embryo transfer

Single may leads to lower live birth compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.67 [0.59, 0.75]
  12 studies · 1904 participants
  Low

Single vs multiple embryo transfer

Single probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 0.16 [0.12, 0.22]
  13 studies · 1952 participants
  Moderate

Single vs multiple embryo transfer

Single may leads to lower clinical pregnancy compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.7 [0.64, 0.77]
  10 studies · 1860 participants
  Low

Single vs multiple embryo transfer

Single showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 0.96 [0.66, 1.42]
  7 studies · 1560 participants
  Low