Cochrane · systematic review · CD014811
Continuous infusion versus bolus injection of loop diuretics for acute heart failure
Rasoul, D, Zhang, J, Farnell, E, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 3 · 42.9%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Continuous infusion of intravenous loop diuretics compared to bolus injection of intravenous loop diuretics for adults (aged greater than 18 years) with acute heart failure
Population: adults (aged greater than 18 years) with acute heart failure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Daily fluid balance in millilitres (measured from admission to discharge) Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics | no estimate extracted | 2 studies · 169 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Net weight loss (measured from admission to discharge) Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics | no estimate extracted | 5 studies · 497 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality (from admission to discharge) Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics | RR 1.53 [0.81, 2.9] | 5 studies · 530 participants | Low Downgraded: risk of bias, imprecision |
Cardiovascular mortality ‐ not measured Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics | no estimate extracted | NR | No studies |
Length of hospital stay (from admission to discharge) Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics | no estimate extracted | 4 studies · 211 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Readmission to hospital following discharge Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics | RR 0.85 [0.63, 1.16] | 3 studies · 400 participants | Low Downgraded: risk of bias, imprecision |
Acute kidney injury (adverse event) (from admission to discharge) Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics | RR 1.02 [0.7, 1.49] | 3 studies · 491 participants | Low Downgraded: risk of bias, imprecision |