Findings

What do systematic reviews say?

577 questions · 585 findings · 57 reviews

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No studies found 61 · 10.4%GRADE not reported 46 · 7.9%Very low 206 · 35.2%Low 210 · 35.9%Moderate 52 · 8.9%High 10 · 1.7%

Intervention not reported

Survival timea · people with severe dementia

1 finding from 1 review

Enteral tube feeding for people with severe dementia 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1696 participants
Very low

Intervention not reported

Mortalityd · people with severe dementia

1 finding from 1 review

Enteral tube feeding for people with severe dementia 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 234 participants
Very low

Intervention not reported

Quality of Life · people with severe dementia

The review found no eligible studies for this question.

1 finding from 1 review

Enteral tube feeding for people with severe dementia 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Pressure ulcersf · people with severe dementia

1 finding from 1 review

Enteral tube feeding for people with severe dementia 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 351 participants
Very low

Intervention not reported

Pain and comforth No · people with severe dementia

1 finding from 1 review

Enteral tube feeding for people with severe dementia 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 117 participants
Very low

Intervention not reported

Improvement of nutritional parameters (Nutrition)j · people with severe dementia

1 finding from 1 review

Enteral tube feeding for people with severe dementia 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 167 participants
Very low

Lactoferrin supplementation vs control

All‐cause Mortality№ of participants: 5510(11 RCTs) · prevention of sepsis and necrotizing enterocolitis in preterm infants

It is very uncertain whether lactoferrin supplementation changes all‐cause Mortality№ of participants: 5510(11 RCTs) compared with control (very low certainty).

1 finding from 1 review

Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants 2020 · Cochrane Headline outcomes only
RR 0.97 [0.79, 1.2]
Studies not reported
Very low

Lactoferrin supplementation vs control

necrotizing enterocolitis№ of participants: 4874(7 RCTs) · prevention of sepsis and necrotizing enterocolitis in preterm infants

Lactoferrin supplementation showed no clear difference in necrotizing enterocolitis№ of participants: 4874(7 RCTs) compared with control (low certainty).

1 finding from 1 review

Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants 2020 · Cochrane Headline outcomes only
RR 0.9 [0.69, 1.17]
Studies not reported
Low

Lactoferrin supplementation vs control

Any late‐onset sepsis ‐ all infants · prevention of sepsis and necrotizing enterocolitis in preterm infants

Lactoferrin supplementation may leads to lower late onset sepsis№ of participants: 5425(12 RCTs) [Data includes… compared with control (low certainty).

1 finding from 1 review

Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants 2020 · Cochrane Headline outcomes only
RR 0.8 [0.72, 0.89]
Studies not reported
Low

Lactoferrin supplementation vs control

Bacterial sepsis · prevention of sepsis and necrotizing enterocolitis in preterm infants

Lactoferrin supplementation showed no clear difference in bacterial sepsis№ of participants: 3565(8 RCTs) compared with control (low certainty).

1 finding from 1 review

Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants 2020 · Cochrane Headline outcomes only
RR 0.86 [0.74, 1]
Studies not reported
Low

Lactoferrin supplementation vs control

Fungal Infection · prevention of sepsis and necrotizing enterocolitis in preterm infants

Lactoferrin supplementation may leads to lower fungal infection№ of participants: 3266(6 RCTs) compared with control (low certainty).

1 finding from 1 review

Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants 2020 · Cochrane Headline outcomes only
RR 0.23 [0.1, 0.54]
Studies not reported
Low

Lactoferrin supplementation vs control

Chronic lung disease · prevention of sepsis and necrotizing enterocolitis in preterm infants

Lactoferrin supplementation showed no clear difference in chronic lung disease№ of participants: 2984(5 RCTs) compared with control (low certainty).

1 finding from 1 review

Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants 2020 · Cochrane Headline outcomes only
RR 1 [0.89, 1.12]
Studies not reported
Low

Lactoferrin supplementation vs control

Length of hospital stay · prevention of sepsis and necrotizing enterocolitis in preterm infants

1 finding from 1 review

Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Subgroup 1: Length of hospital stay (days) distal to ligament of Treitz · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 1156 participants
Low

Intervention not reported

Subgroup 2: Length of hospital stay (days) distal and proximal to ligament of Treitz · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 190 participants
Low

Intervention not reported

Subgroup 3: Length of hospital stay (days) oral feeding only · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1075 participants
Low

Intervention not reported

Subgroup 4: Length of hospital stay (days) tube feeding with/without oral feeding · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 271 participants
Very low

Intervention not reported

Sensitivity analysis 2: Removing studies with imputed results · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 396 participants
Very low

Intervention not reported

Senstivity analysis 3: Worst case scenario imputation · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 235 participants
Low

Intervention not reported

Senstivity analysis 4: Best case scenario imputation · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 235 participants
Low