Question · asked by 1 review

Lactoferrin supplementation vs control: Chronic lung disease

Lactoferrin supplementation showed no clear difference in chronic lung disease№ of participants: 2984(5 RCTs) compared with control (low certainty).

What each review found

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FindingEffectStudiesGRADE certainty
Lactoferrin supplementation vs control
Chronic lung disease№ of participants: 2984(5 RCTs) · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation showed no clear difference in chronic lung disease№ of participants: 2984(5 RCTs) compared with control (low certainty).
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants (2020) · Cochrane Headline outcomes only
RR 1 [0.89, 1.12]Not reportedLow

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants
2020 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.