Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,296 questions · 1,330 findings · 157 reviews · Headline outcomes only

No studies found 297 · 22.3%GRADE not reported 88 · 6.6%Very low 327 · 24.6%Low 317 · 23.8%Moderate 239 · 18%High 62 · 4.7%

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Quality of life: CFQ‐R respiratory domain: absolute change from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen
1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Exacerbation frequency · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Adverse effects of treatment · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

Oral plus nebulised antibiotics showed no clear difference in adverse effects of treatment compared with oral antibiotics plus nebulised placebo (low certainty).

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Eradication of MRSA · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

Oral plus nebulised antibiotics showed no clear difference in eradication of MRSA compared with oral antibiotics plus nebulised placebo (low certainty).

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Time until next positive MRSA isolate (from clinically relevant respiratory culture) · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics at time of replacement vs no antibiotics at time of replacement

Adverse effects (Death) · adults with replacing long‐term indwelling urinary catheters

It is very uncertain whether antibiotics at time of replacement changes adverse effects (Death) compared with no antibiotics at time of replacement (very low certainty).

1 finding from 1 review