Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

61 questions · 61 findings · 6 reviews · Epilepsy

No studies found 14 · 23%GRADE not reported 0 · 0%Very low 8 · 13.1%Low 29 · 47.5%Moderate 8 · 13.1%High 2 · 3.3%

Topiramate vs valproate

Proportion of responders (at least 50% seizure frequency reduction in myoclonic seizures) · people with juvenile myoclonic epilepsy

It is very uncertain whether topiramate changes proportion of responders (at least 50% seizure frequency reduction… compared with valproate (very low certainty).

1 finding from 1 review