Blood loss > 1000 mL · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid probably leads to lower blood loss > 1000 mL compared with placebo/no treatment (moderate certainty).
1 finding from 1 review
Mean blood loss (mL) · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
1 finding from 1 review
Use of additional medical interventions to control PPH · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid probably leads to lower use of additional medical interventions to control PPH compared with placebo/no treatment (moderate certainty).
1 finding from 1 review
Serious maternal morbidity or death · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
1 finding from 1 review
Side effects · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid probably leads to higher side effects compared with placebo/no treatment (moderate certainty).
1 finding from 1 review
Thromboembolic events · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid showed no clear difference in thromboembolic events compared with placebo/no treatment (low certainty).
1 finding from 1 review
Mortality Clinical · patients with upper gastrointestinal bleeding
Tranexamic acid probably leads to lower mortality Clinical compared with placebo (moderate certainty).
1 finding from 1 review
Rebleeding · patients with upper gastrointestinal bleeding
Tranexamic acid may leads to lower rebleeding Clinical and endoscopic assessment compared with placebo (low certainty).
1 finding from 1 review
Thromboembolic events · patients with upper gastrointestinal bleeding
Tranexamic acid probably leads to higher any thromboembolic event Clinical and radiological assessment compared with placebo (moderate certainty).
1 finding from 1 review
Surgery Number of participants who underwent surgery · patients with upper gastrointestinal bleeding
Tranexamic acid probably leads to lower surgery Number of participants who underwent surgery compared with placebo (moderate certainty).
1 finding from 1 review
Blood transfusion · patients with upper gastrointestinal bleeding
It is very uncertain whether tranexamic acid changes transfusion Number needing blood transfusion compared with placebo (very low certainty).
1 finding from 1 review
Has died · patients with upper gastrointestinal bleeding
Tranexamic acid probably leads to lower mortality Number of participants who died compared with cimetidine or lansoprazole (moderate certainty).
1 finding from 1 review
Rebleeding · patients with upper gastrointestinal bleeding
Tranexamic acid probably leads to lower rebleeding Clinical and endoscopic assessment compared with cimetidine or lansoprazole (moderate certainty).
1 finding from 1 review
Surgery Number of participants who underwent surgery · patients with upper gastrointestinal bleeding
Tranexamic acid probably leads to lower surgery Number of participants who underwent surgery compared with cimetidine or lansoprazole (moderate certainty).
1 finding from 1 review
Blood transfusion · patients with upper gastrointestinal bleeding
Tranexamic acid may leads to lower transfusion Number of participants who required at least 1 blood… compared with cimetidine or lansoprazole (low certainty).
1 finding from 1 review
Ibuprofen vs placebo
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Menstrual blood loss: mean loss
Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) showed no clear difference in menstrual blood loss (alkaline hematin method) compared with placebo or active comparators (paracetamol, tranexamic acid); GRADE not reported.
2 findings from 1 review
MD 14.11
Studies not reported
GRADE not reported
MD 0.3
Studies not reported
GRADE not reported
Duration of bleeding (menstrual diary)
Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) showed no clear difference in duration of bleeding (menstrual diary) compared with placebo or active comparators (paracetamol, tranexamic acid); GRADE not reported.
1 finding from 1 review
MD 0.2
Studies not reported
GRADE not reported
Side effects: eye and mouth swelling, stomach cramps, fatigue, irritability (diary record)
1 finding from 1 review
no estimate extracted
2 participants
GRADE not reported
Menstrual blood loss Menstruation "more abundant than normal" (questionnaire)
1 finding from 1 review
no estimate extracted
0 participants
GRADE not reported