Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

117 questions · 119 findings · 9 reviews · Headline outcomes only

No studies found 25 · 21%GRADE not reported 14 · 11.8%Very low 29 · 24.4%Low 27 · 22.7%Moderate 16 · 13.4%High 8 · 6.7%

Summary of findings table ‐ Topical small molecule inhibitors (ruxolitinib) vs placebo

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Topical small molecule inhibitors… showed no clear difference in short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Topical small molecule inhibitors (ruxolitinib) vs placebo

Incidence of serious adverse events · adults with alopecia areata

It is very uncertain whether summary of findings table ‐ Topical small molecule inhibitors… changes incidence of serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs topical treatments

Incidence of mastitis within 6 months postpartum · postpartum breastfeeding women

Antibiotics showed no clear difference in incidence of mastitis within 6 months postpartum ‐ Antibiotics… compared with topical treatments (low certainty).

2 findings from 1 review

Tavaborole 5% solution vs vehicle

Adverse events (directly related to treatment, collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Tavaborole 5% solution probably leads to higher adverse events (directly related to treatment, collected over the… compared with vehicle (moderate certainty).

1 finding from 1 review