Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

28 questions · 37 findings · 2 reviews

No studies found 4 · 10.8%GRADE not reported 0 · 0%Very low 3 · 8.1%Low 7 · 18.9%Moderate 10 · 27%High 13 · 35.1%

Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications)

Complete clearance · people with scabies, 2 to 80 years of ageLocation: India, Pakistan

Oral ivermectin 200 μg/kg (1 to 3 doses) may leads to lower complete clearance ‐ week 1 compared with topical permethrin 5% cream (1 to 3 applications) (low certainty).

5 findings from 1 review
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Oral ivermectin 200 μg/kg (1 to 2 doses) vs topical permethrin 5% lotion (1 to 5 applications)

Complete clearance · people with scabies, 5 to 60 years of ageLocation: Egypt, Pakistan

Oral ivermectin 200 μg/kg (1 to 2 doses) showed no clear difference in complete clearance ‐ week 1 ‐ IVER 1 dose versus PER on 5… compared with topical permethrin 5% lotion (1 to 5 applications) (low certainty).

4 findings from 1 review
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Oral ivermectin 200 μg/kg (1 to 2 doses) vs topical permethrin 5% lotion (1 to 5 applications)

Number of participants with ≥ 1 AE ‐ week 2 ‐ IVER 2 doses versus PER on 5 consecutive nights · people with scabies, 5 to 60 years of ageLocation: Egypt, Pakistan

It is very uncertain whether oral ivermectin 200 μg/kg (1 to 2 doses) changes number of participants with ≥ 1 AE ‐ week 2 ‐ IVER 2 doses versus… compared with topical permethrin 5% lotion (1 to 5 applications) (very low certainty).

1 finding from 1 review

Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications)

Number of participants with ≥ 1 AE ‐ week 4 · people with scabies, 2 to 80 years of ageLocation: India, Pakistan

Oral ivermectin 200 μg/kg (1 to 3 doses) showed no clear difference in number of participants with ≥ 1 AE ‐ week 4 compared with topical permethrin 5% cream (1 to 3 applications) (low certainty).

1 finding from 1 review