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Evidence found and GRADE certainty

28 questions · 37 findings · 2 reviews

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No studies found 4 · 10.8%GRADE not reported 0 · 0%Very low 3 · 8.1%Low 7 · 18.9%Moderate 10 · 27%High 13 · 35.1%

Topical ivermectin vs topical metronidazole

QoL · Participants with rosacea

Topical ivermectin leads to higher HRQOL DLQI, proportion of participants that reported at end of study… compared with topical metronidazole (high certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Topical ivermectin leads to higher participant‐assessed improvement in rosacea severity Likert scale ‐… compared with topical metronidazole (high certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

Proportion of participants with adverse event · Participants with rosacea

Topical ivermectin showed no clear difference in proportion of participants with adverse event compared with topical metronidazole (moderate certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Topical ivermectin leads to higher physician‐assessed improvement in rosacea severity compared with topical metronidazole (high certainty).

1 finding from 1 review

Topical ivermectin vs topical permethrin 5% cream (1 to 3 applications)

Complete clearance · people with scabies, 5 to 80 years of ageLocation: India

Topical ivermectin 1% lotion (1 to 3 applications) showed no clear difference in complete clearance ‐ week 4 compared with topical permethrin 5% cream (1 to 3 applications) (moderate certainty).

1 finding from 1 review

Topical ivermectin vs topical permethrin 5% cream (1 to 3 applications)

Number of participants with ≥ 1 AE ‐ week 4 · people with scabies, 5 to 80 years of ageLocation: India

It is very uncertain whether topical ivermectin 1% lotion (1 to 3 applications) changes number of participants with ≥ 1 AE ‐ week 4 compared with topical permethrin 5% cream (1 to 3 applications) (very low certainty).

1 finding from 1 review

Topical ivermectin vs placebo

Assessment of erythema or telangiectasia ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Topical ivermectin vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical ivermectin 1% lotion/solution (1 to 3 applications)

Complete clearance · people with scabies, 5 to 80 years of ageLocation: Egypt, India

Oral ivermectin 200 μg/kg (1 to 3 doses) showed no clear difference in complete clearance ‐ week 1 compared with topical ivermectin 1% lotion/solution (1 to 3 applications) (low certainty).

3 findings from 1 review

Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical ivermectin 1% lotion/solution (1 to 3 applications)

Number of participants with ≥ 1 AE ‐ week 4 · people with scabies, 5 to 80 years of ageLocation: Egypt, India

It is very uncertain whether oral ivermectin 200 μg/kg (1 to 3 doses) changes number of participants with ≥ 1 AE ‐ week 4 compared with topical ivermectin 1% lotion/solution (1 to 3 applications) (very low certainty).

1 finding from 1 review