Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

97 questions · 108 findings · 7 reviews · Drugs and Alcohol

No studies found 6 · 5.6%GRADE not reported 0 · 0%Very low 49 · 45.4%Low 27 · 25%Moderate 14 · 13%High 12 · 11.1%

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) · patients with the treatment of cocaine dependence

Summary of findings table – disulfiram showed no clear difference in continuous abstinence from cocaine (number of participants who had… compared with placebo or no pharmacological treatment (low certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Point abstinence (number of participants who were abstinent at the end of the treatment) · patients with the treatment of cocaine dependence

Summary of findings table – disulfiram may leads to higher point abstinence (number of participants who were abstinent at the… compared with placebo or no pharmacological treatment (low certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Acceptability ‐ total dropouts · patients with the treatment of cocaine dependence

Summary of findings table – disulfiram showed no clear difference in dropout for any reason (number of participants who did not complete… compared with placebo or no pharmacological treatment (low certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Dropouts due to adverse events · patients with the treatment of cocaine dependence

It is very uncertain whether summary of findings table – disulfiram changes dropout due to adverse events (number of participants who did not… compared with placebo or no pharmacological treatment (very low certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Adverse events as N of participants with at least one adverse event objective · patients with the treatment of cocaine dependence

It is very uncertain whether summary of findings table – disulfiram changes any adverse events (number of participants who experienced at least… compared with placebo or no pharmacological treatment (very low certainty).

1 finding from 1 review

Psychosocial interventions vs no intervention

Point abstinence (number of participants who were abstinent at the end of the treatment) · adults with stimulant use disorder

Summary of findings table ‐ Any psychosocial intervention showed no clear difference in point abstinence, end of treatment compared with no intervention (high certainty).

1 finding from 1 review