Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

89 questions · 93 findings · 8 reviews · Haematology

No studies found 18 · 19.4%GRADE not reported 17 · 18.3%Very low 14 · 15.1%Low 25 · 26.9%Moderate 17 · 18.3%High 2 · 2.2%

Thrombopoietin mimetics vs placebo or usual care

Number of participants with severe or life‐threatening bleeding · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether thrombopoietin mimetics changes number of participants with severe or life‐threatening bleeding compared with placebo or standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with at least 1 bleeding episode · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether the intervention changes number of participants with at least 1 bleeding episode (very low certainty).

1 finding from 1 review

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Number of participants with at least 1 bleeding episode · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation
1 finding from 1 review

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Bleeding: Number of days on which a significant bleeding event occurred3 · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation
1 finding from 1 review

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Number of participants with severe or life‐threatening bleeding · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation

Therapeutic or non‐prophylactic platelet transfusion showed no clear difference in number of participants with severe or life‐threatening bleeding up… compared with prophylactic platelet transfusion (low certainty).

1 finding from 1 review

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Mortality from all causes up to 30 days from study entry · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation
1 finding from 1 review

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Number of platelet transfusions per participant up to 30 days from study entry · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation
1 finding from 1 review

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Bleeding: Number of days on which a significant bleeding event occurred3 · People with a haematological disorder
2 findings from 2 reviews · compare the 2 reviews

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder
2 findings from 2 reviews · compare the 2 reviews

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Number of participants with at least 1 clinically significant bleeding event up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in numbers of participants with at least 1 clinically significant… compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

1 finding from 1 review