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What do systematic reviews say?

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Evidence found and GRADE certainty

70 questions · 70 findings · 10 reviews

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No studies found 18 · 25.7%GRADE not reported 2 · 2.9%Very low 14 · 20%Low 13 · 18.6%Moderate 20 · 28.6%High 3 · 4.3%

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Hospital readmission · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in readmission to hospital following discharge compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Acute kidney injury · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in acute kidney injury (adverse event) (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Platelet transfusion vs open control

Death or dependence (mRS 4 to 6) at day 90 · adults with acute spontaneous intracerebral haemorrhage associated with antiplatelet drug use

Summary of findings table ‐ Platelet transfusion probably leads to higher death or dependence (mRS 4–6) compared with open control (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Platelet transfusion vs open control

Intracerebral haemorrhage expansion by 24 hours · adults with acute spontaneous intracerebral haemorrhage associated with antiplatelet drug use

Summary of findings table ‐ Platelet transfusion showed no clear difference in intracerebral haemorrhage expansion by 24 hours compared with open control (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Platelet transfusion vs open control

All serious adverse events · adults with acute spontaneous intracerebral haemorrhage associated with antiplatelet drug use

Summary of findings table ‐ Platelet transfusion showed no clear difference in all serious adverse events compared with open control (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Platelet transfusion vs open control

Death from any cause · adults with acute spontaneous intracerebral haemorrhage associated with antiplatelet drug use

Summary of findings table ‐ Platelet transfusion showed no clear difference in death from any cause compared with open control (moderate certainty).

1 finding from 1 review

Summary of findings: Fibrin sealant vs usual care

Risk of reoperation or repeat procedure for bleeding within 7 days · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Fibrin sealant changes risk of reoperation or repeat procedure for bleeding within 7 days compared with usual care (very low certainty).

1 finding from 1 review

Tranexamic acid vs placebo

Risk of receiving any allogeneic blood product (data only available for intraoperative blood product use) · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Tranexamic acid changes risk of receiving any allogeneic blood product (data only available… compared with placebo (very low certainty).

1 finding from 1 review

Tranexamic acid vs placebo

Risk of reoperation or repeat procedure for bleeding within 7 days · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Tranexamic acid changes risk of reoperation or repeat procedure for bleeding within 7 days compared with placebo (very low certainty).

1 finding from 1 review