What do systematic reviews say?

Inhaled NO vs control

Inhaled NO showed no clear difference in intraventricular haemorrhage (grade 3 or 4) ‐ Studies of routine use… compared with control (moderate certainty).

• Inhaled nitric oxide for respiratory failure in preterm infants 2017 · Cochrane Headline outcomes only
  RR 0.89 [0.73, 1.09]
  4 studies · 1913 participants
  Moderate

Alglucosidase alfa plus clenbuterol vs alglucosidase alfa plus placebo

The review found no eligible studies for this question.

• Enzyme replacement therapy for late‐onset Pompe disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Alglucosidase alfa plus albuterol vs alglucosidase alfa plus placebo

The review found no eligible studies for this question.

• Enzyme replacement therapy for late‐onset Pompe disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

VAL‐1221 vs alglucosidase alfa

The review found no eligible studies for this question.

• Enzyme replacement therapy for late‐onset Pompe disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Cipaglucosidase plus miglustat vs alglucosidase alfa plus placebo

The review found no eligible studies for this question.

• Enzyme replacement therapy for late‐onset Pompe disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Alglucosidase alfa vs placebo

The review found no eligible studies for this question.

• Enzyme replacement therapy for late‐onset Pompe disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Avalglucosidase alfa vs alglucosidase alfa

The review found no eligible studies for this question.

• Enzyme replacement therapy for late‐onset Pompe disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Higher‐dose anticoagulants vs lower‐dose anticoagulants

It is very uncertain whether higher‐dose anticoagulants changes necessity for additional respiratory support compared with lower‐dose anticoagulants (very low certainty).

• Anticoagulants for people hospitalised with COVID‐19: a rapid review 2022 · Cochrane Headline outcomes only
  RR 0.54 [0.12, 2.47]
  3 studies · 3407 participants
  Very low

Anticoagulant vs no treatment

The review found no eligible studies for this question.

• Anticoagulants for people hospitalised with COVID‐19: a rapid review 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hands and knees posture vs other postures

• Maternal postures for fetal malposition in labour for improving the health of mothers and their infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Lateral postures vs other postures

The review found no eligible studies for this question.

• Maternal postures for fetal malposition in labour for improving the health of mothers and their infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Restricted vs standard fluid management

It is very uncertain whether restricted changes incidence of noninvasive (nasal CPAP or nasal ventilation)… compared with standard fluid management (very low certainty).

• Fluid restriction in the management of transient tachypnea of the newborn 2021 · Cochrane Headline outcomes only
  RR 0.4 [0.14, 1.17]
  2 studies · 150 participants
  Very low

Salbutamol vs placebo/no treatment

• Salbutamol for transient tachypnea of the newborn 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 228 participants
  Very low

Regional (spinal, epidural, caudal) vs general anaesthesia

Regional (spinal, epidural, caudal) showed no clear difference in use of post‐operative respiratory support compared with general anaesthesia (low certainty).

• Regional (spinal, epidural, caudal) versus general anaesthesia in preterm infants undergoing inguinal herniorrhaphy in… 2015 · Cochrane Headline outcomes only
  RR 0.09 [0.01, 1.64]
  3 studies · 98 participants
  Low

Diaphragm‐triggered non‐invasive vs other non‐invasive respiratory support

• Diaphragm‐triggered non‐invasive respiratory support in preterm infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

HFNC vs standard oxygen therapy

HFNC may leads to lower treatment failure (escalation of respiratory therapy to NIV, NIPPV… compared with standard oxygen therapy (low certainty).

• High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
  RR 0.62 [0.45, 0.86]
  15 studies · 3044 participants
  Low

HFNC vs NIPPV or NIV

It is very uncertain whether HFNC changes adverse events Respiratory infection (pneumonia) compared with NIPPV or NIV (very low certainty).

• High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
  RR 0.51 [0.17, 1.52]
  3 studies · 1750 participants
  Very low

HFNC vs NIPPV or NIV

• High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1086 participants
  Low

HFNC vs standard oxygen therapy

HFNC showed no clear difference in adverse events Respiratory infection (pneumonia) Nasal mucosa or… compared with standard oxygen therapy (moderate certainty).

• High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
  RR 0.72 [0.48, 1.09]
  4 studies · 1057 participants
  Moderate

HFNC vs standard oxygen therapy

• High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 600 participants
  Very low