Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

118 questions · 122 findings · 23 reviews

No studies found 24 · 19.7%GRADE not reported 6 · 4.9%Very low 43 · 35.2%Low 30 · 24.6%Moderate 14 · 11.5%High 5 · 4.1%

Long‐term red cell transfusion vs no transfusion

TIA · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

It is very uncertain whether long‐term red cell transfusion changes TIA compared with no transfusion (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

Stroke · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

It is very uncertain whether long‐term red cell transfusion changes clinical stroke compared with no transfusion (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

All‐cause mortality · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

It is very uncertain whether long‐term red cell transfusion changes all‐cause mortality compared with no transfusion (very low certainty).

1 finding from 1 review

Intervention not reported

Use of one or more red blood cell transfusions (low and high dose of EPO) during initial hospital stay · preterm infants with low birth weight

It is very uncertain whether the intervention changes use of one or more red blood cell transfusions (low and high dose of… (very low certainty).

1 finding from 1 review

Intervention not reported

Rate of RBC transfusion (total number of participants who required at least one unit of red blood cell transfusion) Time: perioperative and postoperative periods · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

The intervention showed no clear difference in rate of RBC transfusion (total number of participants who required… (low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Incidence of TIA · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

It is very uncertain whether long‐term red cell transfusion changes incidence of TIA compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Measures of neurological impairment ‐ not reported · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

The review found no eligible studies for this question.

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Quality of life ‐ not reported · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

The review found no eligible studies for this question.

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Stroke · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes clinical stroke compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

All‐cause mortality · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes all‐cause mortality compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Incidence of TIA · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes incidence of TIA compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Measures of neurological impairment ‐ not reported · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

The review found no eligible studies for this question.

1 finding from 1 review