Cochrane · systematic review · CD011732
Effectiveness of tranexamic acid in reducing blood loss during cytoreductive surgery for advanced ovarian cancer
Kietpeerakool, C, Supoken, A, Laopaiboon, M, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 44.4%Low 5 · 55.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Estimated total blood loss (mL) | no estimate extracted | 1 study · 100 participants | Low Downgraded: risk of bias, imprecision |
Number of transfused units of red blood cell (RBC) | no estimate extracted | 1 study · 100 participants | Low Downgraded: risk of bias |
Number of transfused units of plasma | no estimate extracted | 1 study · 100 participants | Low Downgraded: risk of bias |
Rate of RBC transfusion (total number of participants who required at least one unit of red blood cell transfusion) Time: perioperative and postoperative periods | RR 0.68 [0.4, 1.15] | 1 study · 100 participants | Low Downgraded: risk of bias |
Rate of plasma transfusion (total number of participants who required at least one unit of plasma transfusion) Time: perioperative and postoperative periods | RR 0.44 [0.15, 1.35] | 1 study · 100 participants | Low Downgraded: risk of bias |
Reoperation (Number of participants with at least one reoperation) Time: perioperative periods | RR 0.83 [0.27, 2.55] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |
Readmission (Number of participants with at least one readmission) Time: perioperative periods) | RR 2.75 [0.94, 8.06] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |
Venous thromboembolic events (number of participants with at least one venous thromboembolic events) Time: 5‐week | RR 0.5 [0.1, 2.61] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |
Arterial thromboembolic events (number of participants with at least one venous thromboembolic events) Time: 5‐week | RR 0.33 [0.01, 7.99] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |