Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

118 questions · 122 findings · 23 reviews

No studies found 24 · 19.7%GRADE not reported 6 · 4.9%Very low 43 · 35.2%Low 30 · 24.6%Moderate 14 · 11.5%High 5 · 4.1%

Long‐term red cell transfusion vs no transfusion

Adverse events associated with transfusion · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

It is very uncertain whether long‐term red cell transfusion changes adverse events associated with transfusion compared with no transfusion (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

Long‐term red cell transfusion may leads to lower serious adverse events as a result of sickle cell‐related… compared with no transfusion (low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

It is very uncertain whether long‐term red cell transfusion changes serious adverse events as a result of sickle cell‐related… compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes serious adverse events as a result of sickle cell‐related… compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Red blood cell transfusion vs no transfusion

Erythrocyte alloantibody formation Laboratory assessment · women with postpartum iron deficiency anaemia

It is very uncertain whether red blood cell transfusion changes erythrocyte alloantibody formation Laboratory assessment compared with non‐transfusion (Comparison 2) (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

Stroke · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

Long‐term red cell transfusion probably leads to lower clinical stroke compared with no transfusion (moderate certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

Measures of neurological impairment ‐ not reported · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

The review found no eligible studies for this question.

1 finding from 1 review