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What do systematic reviews say?

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Evidence found and GRADE certainty

184 questions · 196 findings · 42 reviews · Neonatal

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No studies found 32 · 16.3%GRADE not reported 2 · 1%Very low 43 · 21.9%Low 62 · 31.6%Moderate 39 · 19.9%High 18 · 9.2%

Restricted vs standard fluid management

Incidence of hypernatremia (serum sodium > 145 mEq/L) at end of intervention period (proportions) · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of hypernatremia (serum sodium > 145 mEq/L) at end of… compared with standard fluid management (very low certainty).

1 finding from 1 review

Restricted vs standard fluid management

Incidence of hypoglycemia (blood glucose < 40 mg/dL) at end of intervention period (proportions) · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of hypoglycemia (blood glucose < 40 mg/dL) at end of… compared with standard fluid management (very low certainty).

1 finding from 1 review

Restricted vs standard fluid management

Incidence of endotracheal ventilation (proportions) during hospital stay (for infants on no support or noninvasive support at the time of study entry) · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of endotracheal ventilation (proportions) during hospital… compared with standard fluid management (very low certainty).

1 finding from 1 review

Restricted vs standard fluid management

Incidence of noninvasive (nasal CPAP or nasal ventilation) respiratory support during hospital stay · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of noninvasive (nasal CPAP or nasal ventilation)… compared with standard fluid management (very low certainty).

1 finding from 1 review

Inhaled NO vs control

Intraventricular haemorrhage, Papile grade 3/4 · respiratory failure in preterm infants

Inhaled NO showed no clear difference in intraventricular haemorrhage (grade 3 or 4) ‐ Studies with entry… compared with control (high certainty).

2 findings from 1 review

Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration through an endotracheal tube (S‐ETT)

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants with or at risk of respiratory distress syndrome

It is very uncertain whether surfactant administration via laryngeal mask airway (S‐LMA) changes intraventricular haemorrhage grade III and IV Anytime to discharge compared with surfactant administration via endotracheal tube (ETT) with… (very low certainty).

1 finding from 1 review

Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with the intent to rapidly extubate (InSurE)

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants with or at risk of respiratory distress syndrome
1 finding from 1 review