Cochrane · systematic review · CD001691
Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants
Romantsik, O, Smit, E, Odd, DE, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Phenobarbital compared to control for the prevention of intraventricular haemorrhage in preterm infants
Population: preterm infants with or at risk of IVH
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IVH any grade (Papile classification) during hospitalisation Phenobarbital vs control | RR 1 [0.84, 1.19] | 10 studies · 792 participants | Low Downgraded: risk of bias |
Severe IVH (Papile classification) during hospitalisation Phenobarbital vs control | RR 0.88 [0.64, 1.21] | 10 studies · 792 participants | Low Downgraded: risk of bias |
Ventricular dilation or hydrocephalus during hospitalisation Phenobarbital vs control | RR 0.62 [0.31, 1.26] | 4 studies · 271 participants | Very low Downgraded: risk of bias |
Mild neurodevelopmental impairment at 27 months of age Phenobarbital vs control | RR 0.57 [0.15, 2.17] | 1 study · 101 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Severe neurodevelopmental impairment at 9 to 27 months of age Phenobarbital vs control | RR 1.12 [0.44, 2.82] | 2 studies · 153 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Death before discharge Phenobarbital vs control | RR 0.88 [0.64, 1.21] | 9 studies · 740 participants | Low Downgraded: risk of bias |
All deaths during the study Phenobarbital vs control | RR 0.98 [0.72, 1.33] | 10 studies · 792 participants | Low Downgraded: risk of bias |