Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

185 questions · 193 findings · 19 reviews · Haematology

No studies found 47 · 24.4%GRADE not reported 20 · 10.4%Very low 28 · 14.5%Low 66 · 34.2%Moderate 21 · 10.9%High 11 · 5.7%

Intervention not reported

Episodes of febrile neutropenia · patients with prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in episodes of febrile neutropenia (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events requiring discontinuation of CSFs · Prevention and treatment of infectious complications in patients with acute myelogenous leukemia

It is very uncertain whether the intervention changes adverse events requiring discontinuation of CSFs (very low certainty).

1 finding from 1 review

Intervention not reported

All cause mortality subgroup analysis age>60 · Prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in all cause mortality subgroup analysis age>60 (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality subgroup analysis age< 60 · Prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in all‐cause mortality subgroup analysis age< 60 (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality ‐ sensitivity analysis · Prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in all‐cause mortality ‐ sensitivity analysis (high certainty).

1 finding from 1 review

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Bleeding: Number of days on which a significant bleeding event occurred3 · People with a haematological disorder
2 findings from 2 reviews · compare the 2 reviews

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder
2 findings from 2 reviews · compare the 2 reviews

Tixagevimab/cilgavimab vs placebo

Infection with SARS‐CoV‐2 within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Tixagevimab/cilgavimab probably leads to lower infection with SARS‐CoV‐2 within 6 months compared with placebo (moderate certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Development of clinical COVID‐19 symptoms within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab may leads to lower development of clinical COVID‐19 symptoms within 6 months compared with placebo (low certainty).

1 finding from 1 review