Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Summary of findings table ‐ Selective prevention interventions vs control group

Depressive symptoms · preventing mental disorders
2 findings from 1 review

Summary of findings table ‐ Indicated prevention interventions vs control group

Depressive symptoms · preventing mental disorders
2 findings from 1 review

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

Depressive symptoms · preventing mental disorders
2 findings from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

All‐cause mortality · people with cancer who have febrile neutropenia

Pre‐emptive antifungal therapy showed no clear difference in all‐cause mortality compared with empirical antifungal therapy (low certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

Mortality ascribed to fungal infection · people with cancer who have febrile neutropenia

Pre‐emptive antifungal therapy showed no clear difference in mortality ascribed to fungal infection compared with empirical antifungal therapy (low certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

Proportion of antifungal agent use (other than prophylactic use) · people with cancer who have febrile neutropenia

It is very uncertain whether pre‐emptive antifungal therapy changes proportion of antifungal agent use (other than prophylactic use) compared with empirical antifungal therapy (very low certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

Duration of antifungal use (days) · people with cancer who have febrile neutropenia

It is very uncertain whether pre‐emptive antifungal therapy changes duration of antifungal use (days) compared with empirical antifungal therapy (very low certainty).

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

Invasive fungal infection detection · people with cancer who have febrile neutropenia

It is very uncertain whether pre‐emptive antifungal therapy changes invasive fungal infection detection compared with empirical antifungal therapy (very low certainty).

1 finding from 1 review

Intervention not reported

TXA given orally and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…
1 finding from 1 review