Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

241 questions · 247 findings · 31 reviews

No studies found 64 · 25.9%GRADE not reported 6 · 2.4%Very low 32 · 13%Low 73 · 29.6%Moderate 54 · 21.9%High 18 · 7.3%

Pharmaceutical care vs usual care

The proportion of patients with one or more potentially inappropriate medication (PIM) · older people receiving polypharmacy

It is very uncertain whether pharmaceutical care changes the proportion of patients with one or more potentially… compared with usual care (very low certainty).

1 finding from 1 review

Pharmaceutical care vs usual care

The proportion of patients with one or more potential prescribing omission (PPO) · older people receiving polypharmacy

It is very uncertain whether pharmaceutical care changes the proportion of patients with one or more potential prescribing… compared with usual care (very low certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Participants with adverse events ‐ potential immune‐mediated disease Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine showed no clear difference in participants with adverse events ‐ potential immune‐mediated… compared with placebo (moderate certainty).

1 finding from 1 review

Cipaglucosidase plus miglustat vs alglucosidase alfa plus placebo

Treatment‐related AEs: total treatment‐emergent adverse events potentially related to treatment · adults with LOPD

Cipaglucosidase plus miglustat showed no clear difference in treatment‐related AEs: total treatment‐emergent adverse events… compared with alglucosidase alfa plus placebo (low certainty).

1 finding from 1 review

Avalglucosidase alfa vs alglucosidase alfa

Treatment‐related AEs: total treatment‐emergent adverse events potentially related to treatment · adults with LOPD

Avalglucosidase alfa showed no clear difference in treatment‐related AEs: total treatment‐emergent adverse events… compared with alglucosidase alfa (low certainty).

1 finding from 1 review

Prone vs supine

Potential adverse outcomes (extubation) · acute respiratory distress in hospitalised infants and children

It is very uncertain whether summary of findings table ‐ Prone changes potential adverse outcomes (extubation) compared with supine (very low certainty).

1 finding from 1 review