Cochrane · systematic review · CD008165
Interventions to improve the appropriate use of polypharmacy for older people
Cole, JA, Gonçalves-Bradley, DC, Alqahtani, M, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 71.4%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 4 versionsPharmaceutical care compared with usual care for older people receiving polypharmacy
Population: older people receiving polypharmacy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Medication appropriateness (as measured by an implicit tool; lower scores are better) From baseline to Pharmaceutical care vs usual care | no estimate extracted | 8 studies · 947 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
The number of potentially inappropriate medications (PIMs) Pharmaceutical care vs usual care | no estimate extracted | 9 studies · 2404 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
The proportion of patients with one or more potentially inappropriate medication (PIM) Pharmaceutical care vs usual care | RR 0.81 [0.68, 0.98] | 13 studies · 4534 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
The number of potential prescribing omissions (PPOs) Pharmaceutical care vs usual care | no estimate extracted | 3 studies · 691 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
The proportion of patients with one or more potential prescribing omission (PPO) Pharmaceutical care vs usual care | RR 0.5 [0.27, 0.91] | 7 studies · 2765 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hospital admissions Pharmaceutical care vs usual care | no estimate extracted | 14 studies · 4797 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Quality of life Pharmaceutical care vs usual care | no estimate extracted | 16 studies · 7458 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |