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What do systematic reviews say?

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Evidence found and GRADE certainty

603 questions · 627 findings · 69 reviews · Pain, Palliative and Supportive Care

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No studies found 111 · 17.7%GRADE not reported 27 · 4.3%Very low 191 · 30.5%Low 138 · 22%Moderate 100 · 15.9%High 60 · 9.6%

Intervention not reported

Appetite improvement compared with placebo Subjective sense of appetite, responses to · cachexia anorexia syndrome

It is very uncertain whether the intervention changes appetite improvement compared with placebo Subjective sense of… (very low certainty).

1 finding from 1 review

Intervention not reported

Weight improvement compared with placebo % of patients that improved their weight in kg · cachexia anorexia syndrome

It is very uncertain whether the intervention changes weight improvement compared with placebo % of patients that improved… (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Risk for at least one adverse drug reaction (ADR) per participant · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Kappa‐opioid agonists may leads to higher risk for at least one adverse drug reaction (ADR) per patient compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ondansetron vs placebo

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

It is very uncertain whether summary of findings table ‐ Ondansetron changes risk for at least one adverse event per patient compared with placebo (very low certainty).

1 finding from 1 review