Findings

What do systematic reviews say?

25 questions · 26 findings · 3 reviews · Pregnancy and Childbirth

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No studies found 11 · 42.3%GRADE not reported 1 · 3.8%Very low 8 · 30.8%Low 6 · 23.1%Moderate 0 · 0%High 0 · 0%

NSAID (single administration, any dose) vs paracetamol

Need for additional analgesia (6 hours after administration) · women with perineal pain in the early postpartum period

NSAID (single administration, any dose) may leads to lower need for additional analgesia (6 hours after administration) compared with paracetamol (low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
RR 0.28 [0.12, 0.67]
1 study · 59 participants
Low

NSAID (single administration, any dose) vs paracetamol

Maternal drug adverse effects number of women experiencing adverse effects · women with perineal pain in the early postpartum period

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 210 participants
GRADE not reported

NSAID (single administration, any dose) vs paracetamol

Maternal drug adverse effects (6 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID (single administration, any dose) changes maternal drug adverse effects (6 hours after administration) compared with paracetamol (very low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
RR 0.74 [0.27, 2.08]
3 studies · 300 participants
Very low

NSAID (single administration, any dose) vs paracetamol

Neonatal drug adverse effects ‐ not reported · women with perineal pain in the early postpartum period

The review found no eligible studies for this question.

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAID (single administration, any dose) vs paracetamol

Relief of pain · women with perineal pain in the early postpartum period

NSAID (single administration, any dose) may leads to higher adequate pain relief (4 hours after administration) compared with paracetamol (low certainty).

2 findings from 1 review

Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
RR 1.54 [1.07, 2.22]
3 studies · 342 participants
Low
Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
RR 1.82 [0.61, 5.47]
2 studies · 99 participants
Very low