Bronchopulmonary dysplasia/chronic lung disease · preterm infants with or at risk for apnea of prematurity
It is very uncertain whether high‐dose changes bronchopulmonary dysplasia/chronic lung disease (BPD) at 36 weeks'… compared with standard‐dose strategies (very low certainty).
3 findings from 1 review
RR 0.72 [0.47, 1.11]
3 studies · 333 participants
Very low
RR 0.68 [0.48, 0.97]
1 study · 238 participants
Low
RR 0.75 [0.6, 0.94]
5 studies · 723 participants
Moderate
Bronchopulmonary dysplasia · preterm infants receiving nasal CPAP
Bubble showed no clear difference in bronchopulmonary dysplasia compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).
1 finding from 1 review
Bronchopulmonary dysplasia/chronic lung disease · preterm infants
Caffeine showed no clear difference in bronchopulmonary dysplasia/chronic lung disease: defined as 28 days… compared with other methylxanthines (low certainty).
1 finding from 1 review
RR 1.4 [0.92, 2.11]
Studies not reported
Low
c) Developmental delay more than two SDs below population mean on a standardized test of development: cognitive delay № of participants: 79(1 RCT) · preterm infants
It is very uncertain whether caffeine changes c) Developmental delay more than two SDs below population mean on a… compared with other methylxanthines (very low certainty).
1 finding from 1 review
RR 0.17 [0.02, 1.37]
Studies not reported
Very low
c) Developmental delay more than two SDs below population mean on a standardized test of development: language delay № of participants: 79(1 RCT) · preterm infants
It is very uncertain whether caffeine changes c) Developmental delay more than two SDs below population mean on a… compared with other methylxanthines (very low certainty).
1 finding from 1 review
RR 0.76 [0.37, 1.58]
Studies not reported
Very low
c) Developmental delay more than two SDs below population mean on a standardized test of development: motor delay № of participants: 79(1 RCT) · preterm infants
It is very uncertain whether caffeine changes c) Developmental delay more than two SDs below population mean on a… compared with other methylxanthines (very low certainty).
1 finding from 1 review
RR 0.5 [0.13, 1.96]
Studies not reported
Very low
Bronchopulmonary dysplasia · preterm infants receiving nasal CPAP
It is very uncertain whether mask changes bronchopulmonary dysplasia compared with prongs (very low certainty).
1 finding from 1 review
Combined outcome of death and bronchopulmonary dysplasia defined as death at any time and oxygen dependency at 36 weeks' postmenstrual age · preterm infants
Prophylactic CPAP probably leads to lower combined outcome of death and bronchopulmonary dysplasia defined as… compared with mechanical ventilation (moderate certainty).
1 finding from 1 review
Pulmonary air leak defined as pneumothorax · preterm infants
Prophylactic CPAP showed no clear difference in pulmonary air leak defined as pneumothorax compared with mechanical ventilation (low certainty).
1 finding from 1 review
Bronchopulmonary dysplasia at 28 days · preterm infants
It is very uncertain whether prophylactic CPAP changes bronchopulmonary dysplasia at 28 days compared with very early CPAP (very low certainty).
1 finding from 1 review
Death or bronchopulmonary dysplasia · preterm infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Pulmonary air leak · preterm infants
1 finding from 1 review
no estimate extracted
72 participants
GRADE not reported
Bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency at 36 weeks postmenstrual age · preterm infants
Prophylactic or very early CPAP showed no clear difference in bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency… compared with supportive care (moderate certainty).
1 finding from 1 review
Death or oxygen requirement at 36 weeks' postmenstrual age · preterm infants
Prophylactic or very early CPAP showed no clear difference in combined outcome of death and bronchopulmonary dysplasia defined as… compared with supportive care (low certainty).
1 finding from 1 review
Pulmonary air leak defined as pneumothorax · preterm infants
Prophylactic or very early CPAP showed no clear difference in pulmonary air leak defined as pneumothorax compared with supportive care (low certainty).
1 finding from 1 review
Bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency at 36 weeks postmenstrual age · preterm infants
Prophylactic CPAP probably leads to lower bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency… compared with mechanical ventilation (moderate certainty).
1 finding from 1 review
Intervention not reported
Incidence of bronchopulmonary dysplasia · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome
The intervention showed no clear difference in incidence of bronchopulmonary dysplasia (low certainty).
1 finding from 1 review
Death or bronchopulmonary dysplasia at 36 weeks PMA · preterm infants with or at risk of respiratory distress syndrome
Surfactant administration via thin catheter (S‐TC) probably leads to lower death or bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual… compared with surfactant administration through an endotracheal tube (S‐ETT) (moderate certainty).
1 finding from 1 review
Bronchopulmonary dysplasia · preterm infants with or at risk of respiratory distress syndrome
Surfactant administration via thin catheter (S‐TC) probably leads to lower bronchopulmonary dysplasia (BPD) among survivors at 36 weeks'… compared with surfactant administration through an endotracheal tube (S‐ETT) (moderate certainty).
1 finding from 1 review
Pulmonary air leak · non‐vigorous neonates born through meconium‐stained amniotic fluid
It is very uncertain whether tracheal suction changes pulmonary air leaks (PAL) compared with no tracheal suction (very low certainty).
1 finding from 1 review