Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

65 questions · 87 findings · 7 reviews · Airways

No studies found 31 · 35.6%GRADE not reported 0 · 0%Very low 16 · 18.4%Low 27 · 31%Moderate 10 · 11.5%High 3 · 3.4%

Intravenous magnesium sulfate + standard care vs placebo + standard care

Proportion of people requiring non‐invasive ventilation · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether intravenous magnesium sulfate + standard care changes proportion of people requiring non‐invasive ventilation compared with placebo + standard care (very low certainty).

1 finding from 1 review

Adaptive servo ventilation (ASV) vs bilevel ventilation

Cardiovascular mortality

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) vs bilevel ventilation

Serious adverse events

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) vs bilevel ventilation

Quality of sleep

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) vs bilevel ventilation

Quality of life

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) vs bilevel ventilation

All‐cause mortality

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) vs bilevel ventilation

Time to life‐saving cardiovascular intervention

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) vs continuous positive airway pressure (CPAP)

Cardiovascular mortality

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) vs continuous positive airway pressure (CPAP)

Serious adverse events

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) vs continuous positive airway pressure (CPAP)

Quality of sleep

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) vs continuous positive airway pressure (CPAP)

All‐cause mortality

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) vs continuous positive airway pressure (CPAP)

Time to life‐saving cardiovascular intervention

The review found no eligible studies for this question.

2 findings from 1 review

Adaptive servo ventilation (ASV) plus best supportive care vs best supportive care alone or inactive control

Cardiovascular mortality

Adaptive servo ventilation (ASV) plus best supportive care probably leads to higher cardiovascular mortality ‐ up to 80 months Number of participants:… compared with best supportive care alone or inactive control (moderate certainty).

1 finding from 1 review