It is very uncertain whether intravenous immunoglobulin plus phototherapy changes use of top‐up transfusion after 1st week of life; all studies compared with phototherapy alone (very low certainty).
It is very uncertain whether anti‐vascular endothelial growth factor therapy changes structural outcome ‐ retinal detachment compared with conventional laser/cryotherapy (very low certainty).
It is very uncertain whether anti‐vascular endothelial growth factor therapy changes structural outcome ‐ complete retinal detachment (unit of analysis:… compared with conventional laser/cryotherapy (very low certainty).
Anti‐vascular endothelial growth factor therapy may leads to lower refractive error ‐ very high myopia ‐ at 30 months of age (unit of… compared with conventional laser/cryotherapy (low certainty).
Anti‐vascular endothelial growth factor therapy showed no clear difference in mortality before discharge from primary hospital compared with conventional laser/cryotherapy (low certainty).
Anti‐vascular endothelial growth factor therapy showed no clear difference in mortality at 30 months of age compared with conventional laser/cryotherapy (low certainty).
It is very uncertain whether anti‐vascular endothelial growth factor therapy changes local adverse effects ‐ corneal opacity requiring corneal transplant… compared with conventional laser/cryotherapy (very low certainty).
It is very uncertain whether anti‐vascular endothelial growth factor therapy changes local adverse effects ‐ lens opacity requiring cataract removal… compared with conventional laser/cryotherapy (very low certainty).
It is very uncertain whether anti‐vascular endothelial growth factor therapy changes recurrence of ROP (up to 6 months of age) compared with conventional laser/cryotherapy (very low certainty).
It is very uncertain whether anti‐vascular endothelial growth factor therapy changes recurrence of ROP (unit of analysis: eyes) compared with conventional laser/cryotherapy (very low certainty).
The review found no eligible studies for this question.
Anti‐vascular endothelial growth factor therapy combined with… may leads to lower structural outcome ‐ retinal detachment (unit of analysis: eyes) compared with laser/cryotherapy (low certainty).
It is very uncertain whether anti‐vascular endothelial growth factor therapy combined with… changes local adverse effects ‐ perioperative retinal haemorrhages (unit of… compared with laser/cryotherapy (very low certainty).
Anti‐vascular endothelial growth factor therapy combined with… may leads to lower recurrence of ROP by 55 weeks' postmenstrual age compared with laser/cryotherapy (low certainty).
The review found no eligible studies for this question.
Sunlight (with or without filters or amplification) probably leads to higher hyperthermia while receiving sunlight or conventional phototherapyg compared with other sources of phototherapy (moderate certainty).
Sunlight (with or without filters or amplification) showed no clear difference in hypothermia while receiving sunlight or conventional phototherapyk compared with other sources of phototherapy (moderate certainty).
Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening probably leads to lower readmission for phototherapy for hyperbilirubinemia compared with visual assessment (moderate certainty).