Cochrane · systematic review · CD013277
Sunlight for the prevention and treatment of hyperbilirubinemia in term and late preterm neonates
Horn, D, Ehret, D, Gautham, KS, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
9
No studies
7
Included studies
NR
No studies 7 · 43.8%Ungraded 0 · 0%Very low 4 · 25%Low 3 · 18.8%Moderate 2 · 12.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Sunlight (with or without filters or amplification) versus no treatment for the prevention and treatment of hyperbilirubinemia in term and late preterm neonates
Population: term and late preterm neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomesa Sunlight (with or without filters or amplification) vs no treatment | no estimate extracted | NR | No studies |
Use of conventional phototherapy, if sunlight (with or without filters or amplification) was first used for prevention or early treatmentc Sunlight (with or without filters or amplification) vs no treatment | no estimate extracted | NR | No studies |
Treatment failure requiring exchange transfusionc,d Sunlight (with or without filters or amplification) vs no treatment | no estimate extracted | NR | No studies |
Acute bilirubin encephalopathyc,e Sunlight (with or without filters or amplification) vs no treatment | no estimate extracted | NR | No studies |
Deathc Sunlight (with or without filters or amplification) vs no treatment | no estimate extracted | NR | No studies |
Rate of rehospitalization within 7 days of discharge for treatment for hyperbilirubinemia Sunlight (with or without filters or amplification) vs no treatment | RR 0.55 [0.27, 1.11] | 1 study · 482 participants | Very low Downgraded: risk of bias, imprecision |
Incidence of jaundice in participantsg Sunlight (with or without filters or amplification) vs no treatment | RR 0.61 [0.45, 0.82] | 1 study · 482 participants | Very low Downgraded: risk of bias, imprecision |
Duration of jaundice (days) Sunlight (with or without filters or amplification) vs no treatment | no estimate extracted | 1 study · 482 participants | Very low Downgraded: risk of bias, imprecision |
Sunlight (with or without filters or amplification) versus other sources of phototherapy for the treatment of hyperbilirubinemia in infants with confirmed hyperbilirubinemia
Population: infants with confirmed hyperbilirubinemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomesa Sunlight (with or without filters or amplification) vs other sources of phototherapy | no estimate extracted | NR | No studies |
Use of conventional phototherapy, if sunlight (with or without filters or amplification) was first used for prevention or early treatmentc Sunlight (with or without filters or amplification) vs other sources of phototherapy | no estimate extracted | NR | No studies |
Treatment failure requiring exchange transfusionc,d Sunlight (with or without filters or amplification) vs other sources of phototherapy | RR 1 [0.06, 15.73] | 2 studies · 621 participants | Low Downgraded: imprecision |
Acute bilirubin encephalopathyc,f Sunlight (with or without filters or amplification) vs other sources of phototherapy | RR 0 | 1 study · 174 participants | Low Downgraded: imprecision |
Hyperthermia while receiving sunlight or conventional phototherapyg Sunlight (with or without filters or amplification) vs other sources of phototherapy | RR 4.39 [2.98, 6.47] | 2 studies · 621 participants | Moderate Downgraded: risk of bias |
Deathc Sunlight (with or without filters or amplification) vs other sources of phototherapy | RR 0 | 1 study · 447 participants | Low Downgraded: imprecision |
Proportion of days of effective treatmenti Sunlight (with or without filters or amplification) vs other sources of phototherapy | RR 1.02 [0.97, 1.06] | 2 studies · 621 participants | Very low Downgraded: risk of bias, indirectness |
Hypothermia while receiving sunlight or conventional phototherapyk Sunlight (with or without filters or amplification) vs other sources of phototherapy | RR 1.06 [0.55, 2.03] | 2 studies · 621 participants | Moderate Downgraded: risk of bias |