Breathlessness (dyspnoea) at 1 week (intensity) Scale 0–10; lower score = less breathlessness · adults with cancer‐related breathlessness (dyspnoea)
1 finding from 1 review
Intervention not reported
Pain: 50% reduction in headache frequency Post‐treatment Lower scores = fewer headaches · Children and adolescents with chronic pain
It is very uncertain whether the intervention changes pain: 50% reduction in headache frequency Post‐treatment Lower… (very low certainty).
1 finding from 1 review
Intervention not reported
Disability Post‐treatment Lower scores = lower reported disability · Children and adolescents with chronic pain
1 finding from 1 review
Intervention not reported
Anxiety Post‐treatment Lower scores = lower reported anxiety · Children and adolescents with chronic pain
1 finding from 1 review
Intervention not reported
Depression Post‐treatment Lower scores = lower reported depression · Children and adolescents with chronic pain
1 finding from 1 review
Intervention not reported
Disability Post‐treatment Lower scores = lower reported disability · Children and adolescents with chronic pain
1 finding from 1 review
Intervention not reported
Anxiety Post‐treatment Lower scores = lower reported anxiety · Children and adolescents with chronic pain
1 finding from 1 review
Intervention not reported
Depression Post‐treatment Lower scores = lower reported depression · Children and adolescents with chronic pain
1 finding from 1 review
Intervention not reported
Pain Post‐treatment Lower scores = lower reported pain intensity · Children and adolescents with chronic pain
1 finding from 1 review
Self‐reported health‐related quality of life (0‐100 scale) Higher scores indicate higher burden of disease (lower quality of life) · patients with fibromyalgia
Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported health‐related quality of life (0‐100 scale) Higher… compared with placebo (low certainty).
1 finding from 1 review
Nausea · participants with advanced cancer who have nausea and vomiting not related to chemotherapy, radiotherapy, or surgery
1 finding from 1 review
Participant‐reported pain intensity VAS (0‐10, lower score = less pain) · adults with neuropathic pain
1 finding from 1 review
Participant‐reported pain intensity VAS (0‐10, lower score = less pain) · adults with neuropathic pain
1 finding from 1 review
Quality of life FACT/the GOG‐Ntx questionnaire scores (0 ‐ 100, lower score = better) · adults with neuropathic pain
1 finding from 1 review
Quality of life SF‐36 bodily pain score (0‐100, lower score = more disability) · adults with neuropathic pain
1 finding from 1 review
Health‐related quality of life end of treatment (0‐80 scale) Higher scores indicate lower health‐related quality of life · patients with fibromyalgia
1 finding from 1 review
Intervention not reported
Total studies: 50 Total participants: 14,926 · people with chronic pain Interventions: duloxetine low dose (< 60 mg), standard dose (60 mg), and high dose (> 60 mg); milnacipran…
1 finding from 1 review
no estimate extracted
50 participants
GRADE not reported
Intervention not reported
Duloxetine high dose RCTs: 14 Participants: 3683 · people with chronic pain Interventions: duloxetine low dose (< 60 mg), standard dose (60 mg), and high dose (> 60 mg); milnacipran…
1 finding from 1 review
no estimate extracted
14 participants
Low
Intervention not reported
Duloxetine standard dose RCTs: 18 Participants: 4959 · people with chronic pain Interventions: duloxetine low dose (< 60 mg), standard dose (60 mg), and high dose (> 60 mg); milnacipran…
1 finding from 1 review
no estimate extracted
18 participants
Moderate
Intervention not reported
Milnacipran high dose RCTs: 2 Participants: 1670 · people with chronic pain Interventions: duloxetine low dose (< 60 mg), standard dose (60 mg), and high dose (> 60 mg); milnacipran…
1 finding from 1 review
no estimate extracted
2 participants
Low