Cochrane · systematic review · CD012704
Systemic corticosteroids for the management of cancer‐related breathlessness (dyspnoea) in adults
Haywood, A, Duc, J, Good, P, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 5 · 83.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Systemic corticosteroids compared with placebo for the management of cancer‐related breathlessness (dyspnoea)
Population: adults with cancer‐related breathlessness (dyspnoea)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Breathlessness (dyspnoea) at 1 week (intensity) Scale 0–10; lower score = less breathlessness Systemic corticosteroids vs placebo | no estimate extracted | 2 studies · 114 participants | Very low Downgraded: risk of bias, imprecision |
Breathlessness (dyspnoea) at 1 week (quality) Cancer Dyspnea Scale Systemic corticosteroids vs placebo | no estimate extracted | 1 study · 29 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Breathlessness (dyspnoea) at 1 week (burden) EORTC QLQ‐C30, FACIT, ESAS Systemic corticosteroids vs placebo | no estimate extracted | 2 studies · 113 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events Systemic corticosteroids vs placebo | no estimate extracted | 2 studies · 157 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Patient satisfaction with treatment Systemic corticosteroids vs placebo | no estimate extracted | NR | No studies |
Participant withdrawal from trial Systemic corticosteroids vs placebo | no estimate extracted | 2 studies · 173 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |