What do systematic reviews say?

Dexmedetomidine vs traditional sedative agents

• Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 1120 participants
  Low

Dexmedetomidine vs traditional sedative agents

It is very uncertain whether dexmedetomidine changes risk of delirium compared with traditional sedative agents (very low certainty).

• Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
  RR 0.85 [0.63, 1.14]
  7 studies · 1624 participants
  Very low

Dexmedetomidine vs traditional sedative agents

It is very uncertain whether dexmedetomidine changes risk of coma compared with traditional sedative agents (very low certainty).

• Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
  RR 0.69 [0.55, 0.86]
  1 study · 103 participants
  Very low

Dexmedetomidine vs traditional sedative agents

It is very uncertain whether dexmedetomidine changes incidence of bradycardia compared with traditional sedative agents (very low certainty).

• Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
  RR 2.11 [1.39, 3.2]
  6 studies · 1587 participants
  Very low

Dexmedetomidine vs traditional sedative agents

• Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 85 participants
  GRADE not reported

Dexmedetomidine vs traditional sedative agents

• Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1223 participants
  Very low

Dexmedetomidine vs traditional sedative agents

It is very uncertain whether dexmedetomidine changes mortality compared with traditional sedative agents (very low certainty).

• Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only
  RR 0.99 [0.79, 1.24]
  6 studies · 1584 participants
  Very low

Internal jugular vs subclavian insertion: long‐term catheterization

Internal jugular showed no clear difference in catheter‐related infectious complications ‐ Exit site infection compared with subclavian insertion: long‐term catheterization (low certainty).

• Central venous access sites for the prevention of venous thrombosis, stenosis and infection 2012 · Cochrane Headline outcomes only
  RR 7 [0.88, 55.86]
  1 study · 200 participants
  Low

Internal jugular vs subclavian insertion: long‐term catheterization

Internal jugular showed no clear difference in catheter‐related infectious complications ‐ Port‐related bacteraemia… compared with subclavian insertion: long‐term catheterization (moderate certainty).

• Central venous access sites for the prevention of venous thrombosis, stenosis and infection 2012 · Cochrane Headline outcomes only
  RR 0.35 [0.04, 3.32]
  1 study · 240 participants
  Moderate

Internal jugular vs subclavian insertion: long‐term catheterization

Internal jugular showed no clear difference in catheter‐related thrombotic complications compared with subclavian insertion: long‐term catheterization (moderate certainty).

• Central venous access sites for the prevention of venous thrombosis, stenosis and infection 2012 · Cochrane Headline outcomes only
  RR 1.97 [0.87, 4.48]
  1 study · 240 participants
  Moderate

Internal jugular vs subclavian insertion: long‐term catheterization

Internal jugular showed no clear difference in immediate mechanical complications ‐ Total mechanical complications compared with subclavian insertion: long‐term catheterization (low certainty).

• Central venous access sites for the prevention of venous thrombosis, stenosis and infection 2012 · Cochrane Headline outcomes only
  RR 1 [0.21, 4.84]
  2 studies · 468 participants
  Low

Internal jugular vs subclavian insertion: long‐term catheterization

Internal jugular showed no clear difference in immediate mechanical complications ‐ Major mechanical complications compared with subclavian insertion: long‐term catheterization (low certainty).

• Central venous access sites for the prevention of venous thrombosis, stenosis and infection 2012 · Cochrane Headline outcomes only
  RR 0.33 [0.01, 8.09]
  2 studies · 468 participants
  Low

Internal jugular vs subclavian insertion: long‐term catheterization

Internal jugular showed no clear difference in late mechanical complications compared with subclavian insertion: long‐term catheterization (low certainty).

• Central venous access sites for the prevention of venous thrombosis, stenosis and infection 2012 · Cochrane Headline outcomes only
  RR 1.67 [0.41, 6.79]
  2 studies · 468 participants
  Low